Protective effects of thiazolo[3,2-b]-1,2,4-triazoles on ethanol-induced oxidative stress in mouse brain and liver

Basit Öğe Kaydı
dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.contributor.authorAktay, G
dc.contributor.authorTozkoparan, B
dc.contributor.authorErtan, M
dc.date.accessioned2024-08-04T20:14:53Z
dc.date.available2024-08-04T20:14:53Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of 3-[1-(4-(2-methyIpropyl) phenyl) ethyl] - 1 2,4-triazole-5-th ion e (1) and its bicyclic condensed derivatives 6-benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones (IIa-IIf) were investigated for the prevention of ethanol-induced oxidative stress in liver and brain of mice. Administration of ethanol (0.1 mL/mice, p.o.) resulted in a drop of total thiol groups (T-SH) and non-protein thiol groups (NP-SH), and an increase in thiobarbituric acid reactive substances (TBARS) in both liver and brain tissue of mice (p < 0.001). Among the compounds investigated (at a dose of 200 mg/kg, p.o.), I and IId ameliorated the peroxidative injury in these tissues effectively. Compounds IIa, IIc and IIe improved the peroxidative tissue injury only in brain. These findings suggest that certain condensed thiazolo-triazole compounds may contribute to the control of ethanol-induced oxidative stress in an organ selective manner.en_US
dc.identifier.doi10.1007/BF02977673
dc.identifier.endpage442en_US
dc.identifier.issn0253-6269
dc.identifier.issue4en_US
dc.identifier.pmid15918517en_US
dc.identifier.scopus2-s2.0-22844445903en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage438en_US
dc.identifier.urihttps://doi.org/10.1007/BF02977673
dc.identifier.urihttps://hdl.handle.net/11616/94019
dc.identifier.volume28en_US
dc.identifier.wosWOS:000228809700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPharmaceutical Society Koreaen_US
dc.relation.ispartofArchives of Pharmacal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidant activityen_US
dc.subjectcondensed thiazolo-triazole compoundsen_US
dc.subjectethanol toxicityen_US
dc.subjectnon-steroidal antiinflammatory drugsen_US
dc.subjectoxidative stressen_US
dc.titleProtective effects of thiazolo[3,2-b]-1,2,4-triazoles on ethanol-induced oxidative stress in mouse brain and liveren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu