The Protective Role of Molsidomine on the Cisplatin-Induced Ototoxicity

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridKIZILAY, Ahmet/0000-0003-3048-6489
dc.authoridsapmaz, emrah/0000-0002-0346-8704
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidKIZILAY, Ahmet/ABI-8293-2020
dc.authorwosidToplu, Yuksel/AAA-3133-2021
dc.contributor.authorToplu, Yuksel
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorSapmaz, Emrah
dc.contributor.authorKaratas, Erkan
dc.contributor.authorPolat, Alaattin
dc.contributor.authorKizilay, Ahmet
dc.date.accessioned2024-08-04T20:38:07Z
dc.date.available2024-08-04T20:38:07Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis experimental study was designed to investigate the protective effects of molsidomine (MOL) on against cisplatin-induced ototoxicity (CIO). To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status [including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPX), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI)] were evaluated. Thirty-two female wistar albino rats were divided into four groups including; control (Group K), cisplatin (Group C), cisplatin plus MOL group (Group CM), and MOL group (Group M). DPOAEs measurements between 0.9961 and 8.0003 Hz as DP-gram and input/output (I/O) functions were performed in the same (left) ear of all rats on days 0, 1st, 5th and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. In the C group, statistically significant DPOAE amplitude reductions were detected at 2.5195, 3.1758, 3.9961, 5.0391, 6.3516 and 8.0039 Hz frequencies (p < 0.05) between 0th and 1st, 0th and 5th and 0th and 12th days' measurements (p < 0.05). Serum level of MDA, TAC and OSI levels were significantly higher in the C group versus K group (p < 0.05). In the CM group, there were no significant differences at all frequencies between 0th and other days' measurements (p[0.05) and the serum levels of all biochemical parameters were shifted toward normal values, similar to the K group (p < 0.05). No significant differences were detected in the either M or K group's measurements. According to these results, cis-platin-related ototoxicity has been significantly prevented by MOL.en_US
dc.identifier.doi10.1007/s12070-014-0718-2
dc.identifier.endpage319en_US
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.issue3en_US
dc.identifier.pmid25032121en_US
dc.identifier.scopus2-s2.0-84897117279en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage314en_US
dc.identifier.urihttps://doi.org/10.1007/s12070-014-0718-2
dc.identifier.urihttps://hdl.handle.net/11616/96391
dc.identifier.volume66en_US
dc.identifier.wosWOS:000422258300017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Otolaryngology and Head & Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectOtotoxicityen_US
dc.subjectMolsidomineen_US
dc.subjectOtoacoustic emissionsen_US
dc.subjectOxidative statusen_US
dc.titleThe Protective Role of Molsidomine on the Cisplatin-Induced Ototoxicityen_US
dc.typeArticleen_US

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