Patients with spontaneous bacterial peritonitis, and malignant and cirrhotic ascites

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dc.authorwosidSari, Ramazan/C-2868-2016
dc.contributor.authorYildirim, B
dc.contributor.authorSari, R
dc.contributor.authorIsci, N
dc.date.accessioned2024-08-04T20:13:45Z
dc.date.available2024-08-04T20:13:45Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Cytokines play a key role in the regulation of cells of the immune system and also have been implicated in the pathogenesis of malignant diseases. Method and Patients: We studied tumor necrosis factor-cl, tumor necrosis factor receptor and C-reactive protein levels in both ascitic fluid and serum in patients with spontaneous bacterial peritonitis (SBP) (n=22), and in the malignant (n=38) and cirrhotic (n=32) ascites. Results: C-reactive protein, tumor necrosis factor-a and tumor necrosis factor receptor levels in the ascitic fluid were found to be elevated in the SBP (p<0.001) and malignant groups (p<0.005) when compared with the sterile cirrhotic group. C-reactive protein levels in the serum were found to be elevated in the SBP group when compared with the sterile cirrhotic (p<0.001) and malignant group (p<0.005). Tumor necrosis factor-a in the serum was significantly elevated in the SBP when compared with the cirrhotic (p<0.005) and malignant ascites (p<0.001). Sensitivity and specificity of ascitic fluid CRP in discriminating malignant 84% and 67% and SBP from sterile ascites were 90% and 76%, respectively. Sensitivity and specificity of ascitic fluid TNF-alpha in discriminating malignant 77% and 60% and SBP from sterile ascites were 82% and 66%, respectively. Sensitivity and specificity of TNF-r p60 in discriminating malignant 74% and 70% and SBP from sterile ascites were 80% and 76%, respectively. Conclusion: The sensitivity and specificity of ascitic fluid CRP, TNF-alpha and TNF-r values were found to be similar. Ascitic fluid C-reactive protein to differentiate SBP and malignant ascitic from cirrhotic ascites are cheap, practical and safe tests used in the differential diagnosis of ascites.en_US
dc.identifier.endpage280en_US
dc.identifier.issn0027-9684
dc.identifier.issn1943-4693
dc.identifier.issue2en_US
dc.identifier.pmid15712792en_US
dc.identifier.scopus2-s2.0-13444270449en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage276en_US
dc.identifier.urihttps://hdl.handle.net/11616/93808
dc.identifier.volume97en_US
dc.identifier.wosWOS:000226701600039en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatl Med Assocen_US
dc.relation.ispartofJournal of The National Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectascitesen_US
dc.subjectdiagnosisen_US
dc.subjecttumor necrosis factoren_US
dc.subjecttumor necrosis factor receptoren_US
dc.subjectCRPen_US
dc.titlePatients with spontaneous bacterial peritonitis, and malignant and cirrhotic ascitesen_US
dc.typeArticleen_US

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