Preparation of hybrid PU/PCL fibers from steviol glycosides via electrospinning as a potential wound dressing materials

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridMEHTEROGLU, Ezgi/0000-0001-7478-7625
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidKöytepe, Süleyman/AAA-4168-2021
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.contributor.authorMehteroglu, Ezgi
dc.contributor.authorCakmen, Ayse B.
dc.contributor.authorAksoy, Busra
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:47:12Z
dc.date.available2024-08-04T20:47:12Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the synthesis and application of biocompatible steviol glycosides based polyurethane/poly (epsilon-caprolactone) (PU/PCL) fibers was performed by electrospinning as a potential wound dressing materials that can be used for the closure of nonhealing wounds. During electrospinning, steviol glycoside-based polyurethane structures were used in blend formation with poly (epsilon-caprolactone) for easy producibility. Steviol glycosides are a natural abundant and easily accessible source as the main component of the wound dressing material due to their free hydroxyl groups, high biocompatibility, and hydrophilicity. The structure of steviol glycosides is composed of saccharide units and the free OH groups. Thus, steviol glycosides act as a crosslinker within the polyurethane structure and provides mechanical strength. For the production of steviol glycosides based PU/PCL fibers first, the steviol glycosides as a monomer were isolated from the stevia rebudiana. Then, polyurethane structures containing stevia glycoside were synthesized with hexamethylene diisocyanate, lactose and PEG-200 by solution polymerization technique. PCL was added to the prepared polyurethanes in a ratio of 1:2 and formation of nanofiber structure. The prepared wound dressing material was characterized by Fourier transform infrared, atomic force microscopy, and scanning electron microscope techniques. Swelling degree, water content and oxygen permeability assay of the steviol glycosides based PU/PCL wound dressing material was determined. In biocompatibility test, cell viability value of PU/PCL fibrous materials in indirect cytotoxicity test was determined as 86.9% and cell adhesion on hybrid PU/PCL fibers was showed as morphological. In accordance with this target, the steviol glycosides based PU/PCL wound dressing material can be produced easily and low cost. As a result, the wound dressing materials obtained with their high biocompatibility and low costs will be an effective and fast method for the healing of open wounds of diabetics.en_US
dc.description.sponsorshipInonu University Research Fund [FCD-2017-956]en_US
dc.description.sponsorshipThis work was financially supported by Inonu University Research Fund (FCD-2017-956).en_US
dc.identifier.doi10.1002/app.49217
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue40en_US
dc.identifier.scopus2-s2.0-85081261401en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.49217
dc.identifier.urihttps://hdl.handle.net/11616/99214
dc.identifier.volume137en_US
dc.identifier.wosWOS:000553544900032en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiomaterialsen_US
dc.subjectbiomedical applicationsen_US
dc.subjectbiopolymers and renewable polymersen_US
dc.titlePreparation of hybrid PU/PCL fibers from steviol glycosides via electrospinning as a potential wound dressing materialsen_US
dc.typeArticleen_US

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