The protective effects of apocynin in hyperoxic lung injury in neonatal rats

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dc.authoridturgut, hatice/0000-0002-0490-7852
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridDeveci, Mehmet Fatih/0000-0002-3328-4156
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authorwosidturgut, hatice/IZQ-4154-2023
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidDeveci, Mehmet Fatih/IYS-3534-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorGokce, Ismail Kursat
dc.contributor.authorTekin, Suat
dc.contributor.authorTaslidere, Asli Cetin
dc.contributor.authorTurgut, Hatice
dc.contributor.authorTanbek, Kevser
dc.contributor.authorGul, Cemile Ceren
dc.date.accessioned2024-08-04T20:50:43Z
dc.date.available2024-08-04T20:50:43Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim Inflammation and oxidate stress are significant factors in the pathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study is to investigate the efficacy of apocynin (APO), an anti-inflammatory, antioxidant, and antiapoptotic drug, in the prophylaxis of neonatal hyperoxic lung injury. Method This experimental study included 40 neonatal rats divided into the control, APO, BPD, and BPD + APO groups. The control and APO groups were kept in a normal room environment, while the BPD and BPD + APO groups were kept in a hyperoxic environment. The rats in the APO and BPD + APO groups were administered intraperitoneal APO, while the control and BPD rats were administered ordinary saline. At the end of the trial, lung tissue was evaluated with respect to the degree of histopathological injury, apoptosis, oxidant and antioxidant capacity, and severity of inflammation. Result The BPD and BPD + APO groups exhibited higher mean histopathological injury and alveolar macrophage scores compared to the control and APO groups. Both scores were lower in the BPD + APO group in comparison to the BPD group. The BPD + APO group had a significantly lower average of TUNEL positive cells than the BPD group. The lung tissue examination indicated significantly higher levels of mean malondialdehyde (MDA), total oxidant status (TOS), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta) in the BPD group compared to the control and APO groups. While the TNF-alpha and IL-1 beta levels of the BPD + APO group were similar to that of the control group, the MDA and TOS levels were higher compared to the controls and lower compared to the BPD group. The BPD group demonstrated significantly lower levels/activities of mean total antioxidant status, glutathione reductase, superoxide dismutase, glutathione peroxidase in comparison to the control and APO groups. While the mean antioxidant enzyme activity of the BPD + APO group was lower than the control group, it was significantly higher compared to the BPD group. Conclusion This is the first study in the literature to reveal through an experimental neonatal hyperoxic lung injury that APO, an anti-inflammatory, antioxidant, and antiapoptotic drug, exhibits protective properties against the development of BPD.en_US
dc.description.sponsorshipResearch Fund of the Inonu University [TSA-2018-1065]en_US
dc.description.sponsorshipThis study was supported by the Research Fund of the Inonu University, Project Number: TSA-2018-1065.en_US
dc.identifier.doi10.1002/ppul.25707
dc.identifier.endpage121en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue1en_US
dc.identifier.pmid34581514en_US
dc.identifier.scopus2-s2.0-85116265154en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.25707
dc.identifier.urihttps://hdl.handle.net/11616/100236
dc.identifier.volume57en_US
dc.identifier.wosWOS:000703211000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-inflammatoryen_US
dc.subjectantioxidanten_US
dc.subjectapocyninen_US
dc.subjectbronchopulmonary dysplasiaen_US
dc.subjectchronic lung diseaseen_US
dc.subjectnewbornen_US
dc.titleThe protective effects of apocynin in hyperoxic lung injury in neonatal ratsen_US
dc.typeArticleen_US

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