Determination of the presence of carbapenemase enzymes in carbapenem-resistant Pseudomonas aeruginosa isolates by susceptibility test based algorithm

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dc.contributor.authorOcal, Murat
dc.contributor.authorBuyukyanbolu, Ecem
dc.contributor.authorKarakus, Mehmet
dc.contributor.authorKoca, Oznur
dc.contributor.authorTanriverdi, Seren
dc.contributor.authorErdogan, Fatma
dc.contributor.authorComert, Fusun
dc.date.accessioned2026-04-04T13:35:09Z
dc.date.available2026-04-04T13:35:09Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractPurpose: Phenotypic methods have been proposed for the detection of carbapenemase production. These tests can have slower turnaround times. With the sensitivity-based algorithm described by Gill et al. will be possible to detect the carbapenemase. Methods: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates from three hospitals between January 2017 and December 2021 were included. The modified carbapenemase-inactivation-method(mCIM) and two algorithms were used, defined as primary algorithm, i.e. ceftazidime and cefepime non-susceptible in addition to imipenem or meropenem resistance and secondary algorithm, i.e. ceftolozane/tazobactam non-susceptible in addition to imipenem or meropenem resistance. PCR testing was performed on all isolates. Results: 256 CRPA isolates were included in the study. When the primary or secondary algorithm criteria were applied, there were 173 isolates that met one or both of them. Of these, 29 were CIM-positive isolates. Conclusion: In our study, the use of the algorithm reduced the need for CIM testing by 32 %.
dc.description.sponsorshipThis project was internally funded by authors.
dc.identifier.doi10.1016/j.diagmicrobio.2024.116495
dc.identifier.issn0732-8893
dc.identifier.issn1879-0070
dc.identifier.issue4
dc.identifier.orcid0000-0002-0449-0356
dc.identifier.orcid0000-0003-2241-6026
dc.identifier.pmid39244843
dc.identifier.scopus2-s2.0-85203267075
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2024.116495
dc.identifier.urihttps://hdl.handle.net/11616/109657
dc.identifier.volume110
dc.identifier.wosWOS:001313149700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectP. aeruginosa
dc.subjectCarbapenemase
dc.subjectAlgorithm
dc.subjectCIM
dc.titleDetermination of the presence of carbapenemase enzymes in carbapenem-resistant Pseudomonas aeruginosa isolates by susceptibility test based algorithm
dc.typeArticle

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