Hesperidin protects testicular and spermatological damages induced by cisplatin in rats

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridDOĞAN, Halef/0000-0003-1365-1729
dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidDOĞAN, Halef/AAA-9951-2020
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.contributor.authorKaya, K.
dc.contributor.authorCiftci, O.
dc.contributor.authorCetin, A.
dc.contributor.authorDogan, H.
dc.contributor.authorBasak, N.
dc.date.accessioned2024-08-04T20:40:22Z
dc.date.available2024-08-04T20:40:22Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe clinic usage of cisplatin, an anticancer drug, is limited due to it has many side effects in many systems and organs. In this context, it was aimed to investigate the protective effect of hesperidin, a citrus flavonoid, on testicular and spermatological damages induced by cisplatin in rats. The rats were randomly divided into four groups. The first group was kept as a control. In the second groups, cisplatin was given at the single dose of 7mgkg(-1) intraperitoneally. In the third group, hesperidin was orally administered at the dose of 50 mg/kgday(-1) for 14days. In the fourth group, cisplatin and hesperidin were given together at the same doses. Cisplatin treatment caused significant reductions enzymatic (SOD, CAT and GPx) and nonenzymatic (GSH) antioxidants and significant induction level of TBARS. In addition, cisplatin treatment caused decreased sperm motility, epididymal sperm concentration, increased abnormal sperm rate and histopathological damage. In contrast, hesperidin treatment significantly attenuated the harmful effects. In conclusion, this study clearly demonstrated that hesperidin has protective effects on cisplatin-induced reproductive system toxicity depending on its antioxidant properties. Thus, it is thought that hesperidin may be useful against cisplatin toxicity in patients with cancer in terms of reproductive system.en_US
dc.identifier.doi10.1111/and.12332
dc.identifier.endpage800en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue7en_US
dc.identifier.pmid25220503en_US
dc.identifier.scopus2-s2.0-84938290146en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage793en_US
dc.identifier.urihttps://doi.org/10.1111/and.12332
dc.identifier.urihttps://hdl.handle.net/11616/96883
dc.identifier.volume47en_US
dc.identifier.wosWOS:000358865400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjecthesperidinen_US
dc.subjectoxidative stressen_US
dc.subjectsperm motilityen_US
dc.subjecttestisen_US
dc.titleHesperidin protects testicular and spermatological damages induced by cisplatin in ratsen_US
dc.typeArticleen_US

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