Nasopharyngeal carriage, antimicrobial susceptibility, serotype distribution and clonal relatedness of Streptococcus pneumoniae isolates in healthy children in Malatya, Turkey

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dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authoridaktas, elif/0000-0003-3087-5425
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidaktas, elif/ACL-9792-2022
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorBayraktar, MR
dc.contributor.authorDurmaz, B
dc.contributor.authorKalcioglu, MT
dc.contributor.authorDurmaz, R
dc.contributor.authorCizmeci, Z
dc.contributor.authorAktas, E
dc.date.accessioned2024-08-04T20:14:57Z
dc.date.available2024-08-04T20:14:57Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aims of this study were to assess the nasopharyngeal colonisation rate, serogroup and antibiotic susceptibility patterns of Strepto-coccus pneumoniae strains isolated from healthy children. Of 848 children, 162 (19.1 %) were found to be carriers. The carrier rate was significantly higher in the 7-year-old age group. Children from the slums of the city had higher carriage rate (23.7%) than those in the centre of the city (17.7%), but this was not statistically significant. The number of intermediate penicillin-resistant strains was 17 (10.5%). No high-level penicillin-resistant S. pneumoniae strain was found. The rates of resistance to co-trimoxazole, erythromycin, tetracycline and clindamycin were 11.7%, 4.9%, 4.3% and 3.7%, respectively. All isolates were uniformly susceptible to rifampicin, moxifloxacin, levofloxacin and vancomycin. Fourteen different serogroups were identified. The most prevalent serogroups in descending order were 9, 19, 23, 10, 6 and 18, accounting for 76.3% of the isolates. Arbitrarily primed polymerase chain reaction typing of 105 isolates revealed that 25 (23.8%) of the isolates were clonally indistinguishable. This value was 20.9% in children from the central area and 36.8% in those from the slum of the city. There was no relationship between serogroups and genotypes, i.e. strains within the same serogroup yielded the same or different genotypes, and vice versa. In conclusion, serogrouping results give a preliminary idea about the possible coverage of a future pneumococcal vaccine. Penicillin G is still a suitable agent for the empirical treatment of pneumococcal infections in our population. Living in the slum of the city may lead to both increased carriage and clustering rates of S. pneumoniae among healthy children. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijantimicag.2005.06.014
dc.identifier.endpage246en_US
dc.identifier.issn0924-8579
dc.identifier.issn1872-7913
dc.identifier.issue3en_US
dc.identifier.pmid16118046en_US
dc.identifier.scopus2-s2.0-24044501884en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijantimicag.2005.06.014
dc.identifier.urihttps://hdl.handle.net/11616/94075
dc.identifier.volume26en_US
dc.identifier.wosWOS:000232211600010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectcolonisation rateen_US
dc.subjectdrug resistanceen_US
dc.subjectserogroupingen_US
dc.subjectgenotypingen_US
dc.titleNasopharyngeal carriage, antimicrobial susceptibility, serotype distribution and clonal relatedness of Streptococcus pneumoniae isolates in healthy children in Malatya, Turkeyen_US
dc.typeArticleen_US

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