Plasma homocysteine levels in patients with isolated coronary artery ectasia

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dc.authoridBicer, Asuman/0000-0001-7766-9560
dc.authorwosidBicer, Asuman/ABF-3339-2020
dc.contributor.authorTurhan, H
dc.contributor.authorErbay, AR
dc.contributor.authorYasar, AS
dc.contributor.authorBicer, A
dc.contributor.authorSahin, O
dc.contributor.authorNurcan, B
dc.contributor.authorYetkin, E
dc.date.accessioned2024-08-04T20:15:01Z
dc.date.available2024-08-04T20:15:01Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Hyperhomocysteinemia is recognized as an independent risk factor for arterial disease including coronary artery disease, cerebrovascular disease and peripheral vascular disease. Previously, an association between increased plasma homocysteine level and peripheral arterial aneurysms has been reported. However, the relationship between coronary artery ectasia (CAE) and plasma homocysteine level has not been investigated. Accordingly, this study was designed to investigate plasma homocysteine level in patients with isolated CAE. Methods: Thirty-two patients with isolated CAE without significant stenosis and 30 control subjects with angiographically normal coronary arteries were included in this study. Fasting plasma homocysteine concentrations were measured by Florescence Polarization Immunoassay method using homocysteine kids. Hyperhomocysteinemia is defined as plasma homocysteine levels above the 95th percentile of the control subjects (13.6 mu mol/l). Results: According to the definition of hyperhomocysteinemia, 19 (59%) of patients with isolated CAE had elevated levels of plasma hornocysteine compared to 2 (7%) in the control subjects with angiographically normal coronary arteries (p < 0.001). In addition, patients with isolated CAE had significantly higher levels of plasma homocysteine compared to control subjects (14.9 +/- 4.5 mu mol/l vs. 8.6 +/- 1.9 mu mol/l respectively, p < 0.001). Besides, we detected a significant positive correlation between the number of ectasic segment and plasma homocysteine level (r=0.537, p=0.002). Conclusion: We have shown for the first time an association between elevated plasma homocysteine level and isolated CAE. Larger prospective studies are needed to confirm the role of hyperhomocysteinemia in CAE and to evaluate the usefulness of homocysteine-lowering therapies. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2004.10.025
dc.identifier.endpage162en_US
dc.identifier.issn0167-5273
dc.identifier.issue2en_US
dc.identifier.pmid16168808en_US
dc.identifier.scopus2-s2.0-24944572262en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2004.10.025
dc.identifier.urihttps://hdl.handle.net/11616/94096
dc.identifier.volume104en_US
dc.identifier.wosWOS:000232316500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthomocysteineen_US
dc.subjecthyperhomocysteinemiaen_US
dc.subjectcoronary artery ectasiaen_US
dc.titlePlasma homocysteine levels in patients with isolated coronary artery ectasiaen_US
dc.typeArticleen_US

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