Protective effects of melatonin and vitamin E in acetamiprid-induced nephrotoxicity

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dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorZayman, Emrah
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorGul, Semir
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-08-04T20:47:04Z
dc.date.available2024-08-04T20:47:04Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInvestigation of probable toxic effects of acetamiprid (ACMP) on kidney and comparative analysis of the probable protective effects of vitamin E and melatonin were conducted in the present study. The ethics committee approval was obtained from Inonu University Medical Faculty Ethics Committee. Fifty Balb-c mice were randomly assigned to control, corn oil, ethyl alcohol, ACMP, ACMP + melatonin, ACMP + vitamin E, and ACMP + melatonin + vitamin E groups. At the end of the experiments, rat kidney tissues were incised under anesthesia. Blood samples and kidney tissues were examined. After 21 days of ACMP administration, it was observed that malondialdehyde (MDA), total oxidant status (TOS), BUN, creatinine, IL-6, IL-1 beta, and TNF-alpha levels, histopathological damage, and Caspase-3 immunoreactivity scores increased, and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and total antioxidant status (TAS) levels decreased, and histopathological damages were observed. Melatonin and vitamin E administration led to improvements in oxidative stress parameters, renal functions, inflammatory markers, and histopathological findings. ACMP administration led to nephrotoxicity in rat kidney tissues. Although melatonin and vitamin E administrations were effective on ACMP nephrotoxicity separately, co-administration of both was quite effective. Concomitant use of melatonin and vitamin E could be effective on prevention of toxicity.en_US
dc.identifier.doi10.1007/s11356-019-06754-y
dc.identifier.endpage9213en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue9en_US
dc.identifier.pmid31916150en_US
dc.identifier.scopus2-s2.0-85077615218en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage9202en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-019-06754-y
dc.identifier.urihttps://hdl.handle.net/11616/99138
dc.identifier.volume27en_US
dc.identifier.wosWOS:000524949600033en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetamipriden_US
dc.subjectMelatoninen_US
dc.subjectVitamin Een_US
dc.subjectOxidative stressen_US
dc.subjectNephrotoxicityen_US
dc.titleProtective effects of melatonin and vitamin E in acetamiprid-induced nephrotoxicityen_US
dc.typeArticleen_US

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