Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study

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dc.authoridSahin, Ibrahim/0000-0002-6231-0034;
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosidOzcan, Hamdi/T-8408-2019
dc.contributor.authorCelik, Onder
dc.contributor.authorSahin, Ibrahim
dc.contributor.authorCelik, Nilufer
dc.contributor.authorHascalik, Seyma
dc.contributor.authorKeskin, Lezzan
dc.contributor.authorOzcan, Hamdi
dc.contributor.authorUckan, Ahmet
dc.date.accessioned2024-08-04T20:30:47Z
dc.date.available2024-08-04T20:30:47Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: In addition to the negative effect on fertility, polycystic ovary syndrome (PCOS) has been associated with cardiac pathology. Brain natriuretic peptide (BNP) is a possible marker for cardiac risk, therefore we investigated whether N-terminal pro-B-type BNP (NT-proBNP) increases in women with PCOS compared with healthy women of comparable age and body mass index. METHODS: Thirty women with PCOS and 30 healthy women not suffering from overt cardiac disease were involved in the study. Fasting insulin and serum NT-proBNP levels were measured, and M-Mode echocardiography was performed. Insulin resistance was calculated using the homeostasis model assessment insulin resistance index (BOMA-IR). RESULTS: PCOS subjects had higher NT-proBNP levels than the control subjects (P < 0.001). Abnormal echocardiography indices were detected in 14 of the PCOS subjects (but none of the controls), including valvular heart disease in nine, diastolic dysfunction in two, right ventricular enlargement in one, right atrial enlargement in one and pulmonary hypertension in one. PCOS subjects (n = 30) showed an increased left ventricular mass (LVM) (P < 0.001) and left ventricular posterior wall thickness (LVPWT) (P = 0.006). In addition, NT-proBNP concentration was positively correlated with LVM (r = 0.587, P = 0.001) and negatively correlated with sex-hormone-binding globulin (r = -0.528, P = 0.003). There was a positive correlation between LVM and HOMA-IR (r = 0.295, P = 0.03) while LVPWT was positively correlated with fasting insulin and HOMA-IR (r = 0.335, P = 0.031 and r = 0.346, P = 0.045, respectively) in PCOS subjects (n = 30). CONCLUSION: The present study demonstrated that the level of NT-proBNP was increased in PCOS subjects with asymptomatic heart disease.en_US
dc.identifier.doi10.1093/humrep/dem286
dc.identifier.endpage2998en_US
dc.identifier.issn0268-1161
dc.identifier.issue11en_US
dc.identifier.pmid17855407en_US
dc.identifier.scopus2-s2.0-42949131834en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2992en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/dem286
dc.identifier.urihttps://hdl.handle.net/11616/94518
dc.identifier.volume22en_US
dc.identifier.wosWOS:000251371400026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-terminal pro-B-type brain natriuretic peptideen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectechocardiographyen_US
dc.subjectcardiac diseaseen_US
dc.subjectinsulinen_US
dc.titleDiagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison studyen_US
dc.typeArticleen_US

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