Synthesis of New Cinnamoyl-Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studies

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dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridCaliskan, Eray/0000-0003-2399-4100
dc.authoridAltay Ozturk, Dilara/0000-0003-1126-7416
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authorwosidGORGULU, AHMET/KBA-2787-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidKORAN, KENAN/L-6764-2016
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidCaliskan, Eray/W-6973-2018
dc.contributor.authorCaliskan, Eray
dc.contributor.authorOzturk, Dilara Altay
dc.contributor.authorKoran, Kenan
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.contributor.authorErkan, Sultan
dc.contributor.authorGorgulu, Ahmet Orhan
dc.date.accessioned2024-08-04T20:52:14Z
dc.date.available2024-08-04T20:52:14Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAmino acid conjugates are described by the reaction of amino acids with bioactive organic groups such as vitamins, hormones, flavonoids, steroids, and sugars. In this study, 12 new conjugates were synthesized by reaction of cinnamic acid derivatives with various amino acids. Cytotoxic studies against four different human cancer cells (MCF7, PC-3, Caco-2, and A2780) were carried out by MTT assay method at five different concentrations. The structure-activity relationships based on the cell viability rates were evaluated. To compare the anticancer activities of the compounds using computational chemistry methods, they were docked against A2780 human ovarian cancer, Michigan Cancer Foundation-7 (MCF7), human prostate cancer (PC-3) and human colon epidermal adenocarcinoma (Caco-2) cell lines and compared with the standard 5-Fluorouracil. The results indicate that the efficacy of cinnamic acid derivatives increases with the presence of amino acids. Comet assay was conducted to understand whether the cell deaths occur through DNA damage mechanism and the results exhibit that the changes in the specified parameters were statistically significant (p<0.05). Our study demonstrated that the compounds cause cell death through the formation of DNA damage mechanism.en_US
dc.description.sponsorshipInonu University Scientific Research Unit [TSG-2020-2183]; Bingol University Scientific Research Projects Coordination Unit [FEF.2018.00.003]en_US
dc.description.sponsorshipBiological studies of this work were supported by Inonu University Scientific Research Unit (Project No: TSG-2020-2183) and synthesis parts of this work were produced from Eray Calkan's Ph.D. thesis which was supported by Bingol University Scientific Research Projects Coordination Unit (Project No. FEF.2018.00.003).en_US
dc.identifier.doi10.1002/cbdv.202200426
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue8en_US
dc.identifier.pmid35864058en_US
dc.identifier.scopus2-s2.0-85135537884en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202200426
dc.identifier.urihttps://hdl.handle.net/11616/100826
dc.identifier.volume19en_US
dc.identifier.wosWOS:000837319700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectamino aciden_US
dc.subjectcinnamic aciden_US
dc.subjectcytotoxicityen_US
dc.subjectDNA damageen_US
dc.subjectsynthesisen_US
dc.titleSynthesis of New Cinnamoyl-Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studiesen_US
dc.typeArticleen_US

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