Comparison of intravenous ibuprofen and acetaminophen for postoperative multimodal pain management in bariatric surgery: A randomized controlled trial

Basit Öğe Kaydı
dc.authoridSanli, Mukadder/0000-0003-1009-5536
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridErdogan Kayhan, Gulay/0000-0002-2635-9295
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authorwosidSanli, Mukadder/ABI-8124-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidErdogan Kayhan, Gulay/JVZ-0037-2024
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.contributor.authorKayhan, Gulay Erdogan
dc.contributor.authorSanli, Mukadder
dc.contributor.authorOzgul, Ulku
dc.contributor.authorKirteke, Ramazan
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:44:35Z
dc.date.available2024-08-04T20:44:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.descriptionPerioperative Leadership Summit on Aligning Anesthesiology and Perioperative Services with Value-Based Care / Annual Meeting of the Association of Anesthesia Clinical Directors (AACD) -- MAR 02-04, 2018 -- New Orleans, LAen_US
dc.description.abstractStudy objective: Multimodal analgesic strategies are recommended to decrease opioid requirements and opioid-induced respiratory complications in patients undergoing laparoscopic bariatric surgery. Recent studies have demonstrated that intravenous ibuprofen decreases opioid consumption compared with placebo. The primary aim of this study was to compare the effect of intravenous ibuprofen and intravenous acetaminophen on opioid consumption. We also aimed to compare postoperative pain levels and side effects of the drugs. Design: Randomized, double-blinded study. Setting: University hospital. Patients: Eighty patients, aged 18-65 years, (ASA physical status undergoing laparoscopic sleeve gastrectomy or laparoscopic Roux-en-Y gastric bypass surgery were included in this study. Interventions: Patients were randomized to receive 800 mg ibuprofen or 1 g acetaminophen intravenously every 6 h for the first 24 h following surgery; in addition, patient-controlled analgesia with morphine was administered. Measurements: Postoperative morphine consumption in the first 24 h, visual analog scale (VAS) pain scores at rest and with movement, and opioid related side effects were assessed. In addition, time to passage of flatus, surgical complications, lengths of intensive care unit and hospital stay, and laboratory parameters were recorded. Main results: The mean morphine consumption was 23.94 +/- 13.89 mg in iv ibuprofen group and 30.23 +/- 13.76 mg in the acetaminophen group [mean difference: -6.28 (95% CI, -12.70, 0.12); P = 0.055]. The use of intravenous ibuprofen was associated with reduction in pain at rest (AUC, 1- to 24-h, P < 0.001 and 12- to 24-h, P = 0.021) and pain with movement (AUC, 1-24, 6-24, and 12-24 h, P < 0.001). Intravenous ibuprofen was well tolerated with no serious side effects except dizziness. Conclusions: Intravenous ibuprofen did not significantly reduce opioid consumption compared to intravenous acetaminophen; however, it reduced the severity of pain. Intravenous ibuprofen may be a good alternative to intravenous acetaminophen as part of a multimodal postoperative analgesia in patients undergoing bariatric surgery.en_US
dc.description.sponsorshipAssoc Anesthesia Clin Directorsen_US
dc.description.sponsorshipInonu University Department of Scientific Research Projects [2016/68]en_US
dc.description.sponsorshipWe kindly appreciate for the additional statistical analysis to Associate Prof. Dr. Ertugrul COLAK, Eskisehir Osmangazi University Faculty of Medicine, Department of Biostatistics. This study was supported by Inonu University Department of Scientific Research Projects (Project no: 2016/68).en_US
dc.identifier.doi10.1016/j.jclinane.2018.06.030
dc.identifier.endpage11en_US
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.pmid29935486en_US
dc.identifier.scopus2-s2.0-85048709582en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2018.06.030
dc.identifier.urihttps://hdl.handle.net/11616/98345
dc.identifier.volume50en_US
dc.identifier.wosWOS:000445972900003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Clinical Anesthesiaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIbuprofen intravenous solutionen_US
dc.subjectAcetaminophenen_US
dc.subjectBariatric surgeryen_US
dc.subjectPain, postoperativeen_US
dc.titleComparison of intravenous ibuprofen and acetaminophen for postoperative multimodal pain management in bariatric surgery: A randomized controlled trialen_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu