Amine-fnctionalized silver and gold N-heterocyclic carbene complexes: Synthesis, characterization and antitumor properties

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dc.authoridKaloğlu, Murat/0000-0002-2770-5532
dc.authoridDüşünceli, Serpil Demir/0000-0001-8765-4039
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridKızrak, Ümran/0000-0003-1202-9903
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidKaloğlu, Murat/AAA-3956-2021
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidDüşünceli, Serpil Demir/AAA-7160-2021
dc.authorwosidDemir, Serpil/AAI-1740-2019
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.contributor.authorKizrak, Umran
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorDusunceli, Serpil Demir
dc.contributor.authorKaloglu, Murat
dc.contributor.authorMansour, Lamjed
dc.date.accessioned2024-08-04T20:45:38Z
dc.date.available2024-08-04T20:45:38Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDiisopropilamine-tethered benzimidazolium salts have been prepared as precursors for Ag(I)-NHC and Au(I)-NHC complexes. These NHC ligands were metallated with Ag2O on moderate conditions to give novel silver-NHC complexes. Gold-NHC complexes have been obtained by transmetalation using the silver-NHC precursor. The structures of all compounds were characterized by H-1 NMR, C-13 NMR, IR and elemental analysis techniques. The cytotoxic properties of the silver(I) and gold(I) complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cell. IC50 values of these four complexes were determined by the MTS based assay on three human cancer cell lines (SHSY5Y, HTC116 and HEP3B) and human healthy cell line (HF). These silver and gold N-heterocyclic carbene complexes have been highlighted metal-based cancer therapeutic agent with unique structures and functions. These strategies provide exciting opportunities for discovering new type metalodrug. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey [TUBITAK-MHESR 114Z624]en_US
dc.description.sponsorshipThis work was financially supported by the Technological and Scientific Research Council of Turkey (TUBITAK-MHESR 114Z624).en_US
dc.identifier.doi10.1016/j.jorganchem.2018.12.018
dc.identifier.endpage32en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85059511488en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2018.12.018
dc.identifier.urihttps://hdl.handle.net/11616/98595
dc.identifier.volume882en_US
dc.identifier.wosWOS:000456533700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectSilver- and gold-NHC complexesen_US
dc.subjectAntitumor activityen_US
dc.titleAmine-fnctionalized silver and gold N-heterocyclic carbene complexes: Synthesis, characterization and antitumor propertiesen_US
dc.typeArticleen_US

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