The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction

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dc.authoridKuzucu, Mehmet/0000-0002-7786-7687
dc.authoridTaş, Hakan Gökalp/0000-0001-5680-9544;
dc.authorwosidKuzucu, Mehmet/IZE-6900-2023
dc.authorwosidTaş, Hakan Gökalp/HHD-2030-2022
dc.authorwosidYAZICI, GÜLCE/GYR-3499-2022
dc.contributor.authorDelen, Leman Acun
dc.contributor.authorDisli, Zeliha Korkmaz
dc.contributor.authorTas, Hakan G.
dc.contributor.authorKuyrukluyildiz, Ufuk
dc.contributor.authorYazici, Gulce N.
dc.contributor.authorSuleyman, Bahadir
dc.contributor.authorKuzucu, Mehmet
dc.date.accessioned2024-08-04T20:51:45Z
dc.date.available2024-08-04T20:51:45Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPropofol may cause an increase in reactive oxygen species in the body. In this study, we tested the effect of antioxidant thiamine pyrophosphate (TPP) on propofol-induced liver damage. The eighteen rats were split into three groups: HG, healthy; PP, propofol-treated (50 mg/kg) and PT, treated with propofol (50 mg/kg) and TPP (25 mg/kg). Total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) levels were tested together with aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and malondialdehyde (MDA). Histopathological examination of the tissues was performed. We have found that levels of MDA, TOS, ALT, AST, and LDH were all higher in PP group than in HG and PT groups (p < 0.05). In PP group, the TAS and tGSH levels were statistically substantially lower. The PT for oxidants levels showed a statistically significant reduction. In PT group, the levels of antioxidants were found to be considerably higher. The epitheliums, glands, and vascular structures of the PTs were histologically close to normal. By boosting antioxidants, TPP may help to reduce propofol-induced liver damage.en_US
dc.identifier.doi10.4149/gpb_2021043
dc.identifier.endpage70en_US
dc.identifier.issn0231-5882
dc.identifier.issn1338-4325
dc.identifier.issue1en_US
dc.identifier.pmid35253651en_US
dc.identifier.scopus2-s2.0-85125853835en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.4149/gpb_2021043
dc.identifier.urihttps://hdl.handle.net/11616/100515
dc.identifier.volume41en_US
dc.identifier.wosWOS:000821074200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofGeneral Physiology and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectLiveren_US
dc.subjectOxidative stressen_US
dc.subjectPropofolen_US
dc.subjectThiamine pyrophosphateen_US
dc.titleThe effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunctionen_US
dc.typeArticleen_US

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