Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization

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dc.authoridDogan, Berat/0000-0003-4810-1970
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authorwosidTuncay, Görkem/ABI-6418-2020
dc.authorwosidDogan, Berat/AAJ-7288-2020
dc.authorwosidmumcu, akın/ABG-9283-2020
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorTuncay, Gorkem
dc.contributor.authorMumcu, Akin
dc.contributor.authorDogan, Berat
dc.date.accessioned2024-08-04T20:44:33Z
dc.date.available2024-08-04T20:44:33Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate whether a change in the follicular fluid metabolomics profile due to endometrioma is identifiable. Twelve women with ovarian endometriosis (aged<40 years, with a body mass index [BMI] of <30 kg/m(2)) and 12 age- and BMI-matched controls (women with infertility purely due to a male factor) underwent ovarian stimulation for intracytoplasmic sperm injection (ICSI). Follicular fluid samples were collected from both of groups at the time of oocyte retrieval for ICSI. Next, nuclear magnetic resonance (NMR) spectroscopy was performed for the collected follicular fluids. The metabolic compositions of the follicular fluids were then compared using univariate and multivariate statistical analyses of NMR data. Univariate and multivariate statistical analyses of NMR data showed that the metabolomic profiles of the follicular fluids obtained from the women with ovarian endometriosis were distinctly different from those obtained from the control group. In comparison with the controls, the follicular fluids of the women with ovarian endometriosis had statistically significant elevated levels of lactate, beta-glucose, pyruvate, and valine. We conclude that the levels of lactate, beta-glucose, pyruvate, and valine in the follicular fluid of the women with endometrioma were higher than those of the controls.en_US
dc.description.sponsorshipScientific Research Projects Unit of Inonu University [2016/56]en_US
dc.description.sponsorshipThis work was funded by the Scientific Research Projects Unit of Inonu University [grant number 2016/56].en_US
dc.identifier.doi10.1080/19396368.2018.1478469
dc.identifier.endpage47en_US
dc.identifier.issn1939-6368
dc.identifier.issn1939-6376
dc.identifier.issue1en_US
dc.identifier.pmid29806498en_US
dc.identifier.scopus2-s2.0-85047448582en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1080/19396368.2018.1478469
dc.identifier.urihttps://hdl.handle.net/11616/98301
dc.identifier.volume65en_US
dc.identifier.wosWOS:000457437300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofSystems Biology in Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriomaen_US
dc.subjectinfertilityen_US
dc.subjectin vitro fertilizationen_US
dc.subjectmetabolomicsen_US
dc.subjectnuclear magnetic resonanceen_US
dc.titleMetabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilizationen_US
dc.typeArticleen_US

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