Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis

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dc.authoridKeskinruzgar, Aydin/0000-0001-5735-6890
dc.authoridAcibadem, Elif/0000-0003-1000-8383
dc.authorwosidKeskinruzgar, Aydin/HLW-2402-2023
dc.contributor.authorAcibadem, Elif
dc.contributor.authorKeskinruzgar, Aydin
dc.contributor.authorBozdag, Zehra
dc.contributor.authorYavuz, Gunay Yapici
dc.date.accessioned2024-08-04T20:53:14Z
dc.date.available2024-08-04T20:53:14Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundTemporomandibular joint osteoarthritis is a common degenerative joint disease. This disease negatively affects the daily life, speech and chewing functions of patients. ObjectiveThis study aimed to evaluate the effects of intra-articular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis. MethodsA total of 24 Wistar albino rats were used in the study. Rats were divided into four groups: study, saline, control and sham. In both saline and control groups, monosodium iodoacetate was injected intra-articularly to induce osteoarthritis. Alendronate was administered intra-articularly to the study group weekly for 4 weeks. In the saline group, saline was administered by intra-articular injection. At the end of the 12th week, all groups were sacrificed. Mandibular condyle tissues were examined histopathologically. ResultsAccording to the results, osteoarthritic changes in the control group were higher than those in the study group (p < .05). No significant reduction in osteoarthritic changes was observed in the saline group (p > .05). Significant osteoarthritis findings were observed in all groups compared with the sham group (p < .05). ConclusionIntra-articular injection of alendronate was found to have positive results on TMJ osteoarthritis. In addition, it was seen that alendronate has effects on reducing cartilage tissue degeneration and loss of matrix proteins.en_US
dc.identifier.doi10.1111/joor.13396
dc.identifier.endpage121en_US
dc.identifier.issn0305-182X
dc.identifier.issn1365-2842
dc.identifier.issue2en_US
dc.identifier.pmid36437587en_US
dc.identifier.scopus2-s2.0-85143968090en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1111/joor.13396
dc.identifier.urihttps://hdl.handle.net/11616/101057
dc.identifier.volume50en_US
dc.identifier.wosWOS:000893718900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Oral Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalendronateen_US
dc.subjectbisphosphonatesen_US
dc.subjectintra-articular injectionen_US
dc.subjecttemporomandibular joint osteoarthritisen_US
dc.titleTherapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritisen_US
dc.typeArticleen_US

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