The role of CD90 in the differential diagnosis of pleural malignant mesothelioma pulmonary carcinoma and comparison with calretının

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dc.authorid9217en_US
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorAkatlı, Ayşe Nur
dc.contributor.authorÇelik, Muhammet Reha
dc.contributor.authorUlutaş, Hakkı
dc.contributor.authorŞamdancı, Emine
dc.contributor.authorÇolak, Cemil
dc.date.accessioned2017-08-17T06:33:27Z
dc.date.available2017-08-17T06:33:27Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract Pleural Malignant Mesothelioma (MM) is a fatal disease that has been associated with asbestos exposure. Differential diagnosis between the pleural infiltration of pulmonary carcinomas and MM is rather difficult particularly for epitheloid type mesothelioma.We aimed to investigate the utility of CD90, a cancer stem cell marker, in the differential diagnosis of MM and lung carcinoma, its prognostic significance and compare its value with that of Calretinin. Ninety pathology specimens including MM (n:30), pulmonary adenocarcinoma (n:30) and pulmonary squamous cell carcinoma (n:30) were used in this study. Immunohistochemical comparision of CD 90 and Calretinin was made in all groups. Calretinin was positive in 20 cases with MM (64.5 %), and was negative in 10 (32.3 %). CD 90 was positive in 25 of these cases (80 %) and negative in 5 (16 %). On the other hand pulmonary adenocarcinomas and squamous cell carcinomas showed positivity with CD90, 63,6 % and 73 %, respectively. We think that CD 90 has no place in the differential diagnosis between mesothelioma and pulmonary carcinoma because of the low specificity in spite of the high sensitivity.en_US
dc.identifier.citationŞahin, N. Akatlı, A. N. Çelik, M. R. Ulutaş, H. Şamdancı, E. Çolak, C. (2016). The role of CD90 in the differential diagnosis of pleural malignant mesothelioma pulmonary carcinoma and comparison with calretının. Pathology & Oncology Research. 23:487–491.en_US
dc.identifier.doi10.1007/s12253-016-0135-9en_US
dc.identifier.endpage491en_US
dc.identifier.issn1219-4956
dc.identifier.startpage487en_US
dc.identifier.urihttp://link.springer.com/10.1007/s12253-016-0135-9
dc.identifier.urihttps://hdl.handle.net/11616/7606
dc.identifier.volume23en_US
dc.language.isoenen_US
dc.publisherPathology & Oncology Researchen_US
dc.relation.ispartofPathology & Oncology Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesotheliomaen_US
dc.subjectCD 90en_US
dc.subjectPulmonary adenocarcinomaen_US
dc.subjectSquamous cell carcinomaen_US
dc.titleThe role of CD90 in the differential diagnosis of pleural malignant mesothelioma pulmonary carcinoma and comparison with calretınınen_US
dc.typeArticleen_US

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