Protective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn model

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorAra, C
dc.contributor.authorKirimlioglu, H
dc.contributor.authorKarabulut, AB
dc.contributor.authorCoban, S
dc.contributor.authorHascalik, S
dc.contributor.authorCelik, O
dc.contributor.authorYilmaz, S
dc.date.accessioned2024-08-04T20:14:49Z
dc.date.available2024-08-04T20:14:49Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis experimental study was designed to evaluate the degree of adhesion formation and peritoneal tissue levels of malondialdehyde (MDA), reduced glutathione (GSH) and nitric oxide (NO) and the effect of melatonin on these metabolites in a postoperative intraperitoneal adhesion formation model in rats. Thirty adult female Wistar albino rats were subjected to standardized lesions by cecal and uterine horn abrasion and were randomly divided into three groups. Control rats were treated with 5% ethanol. Melatonin treated rats received 4 mg/kg melatonin before closure and for 10 consecutive days intraperitoneally after surgery. Rats in the sham operation group underwent a surgical procedure similar to the other groups however the peritoneal abrasion was not performed. On postoperative day 10 relaparatomy was performed. After the assessment of the adhesions, the rats in each group were sacrificed and peritoneal tissues were harvested to determine the tissue levels of MDA, GSH and NO activity. Adhesion formation scores in the melatonin group were significantly lower than that of control and sham group (p < 0.01 and p < 0.02, respectively). Tissue levels of MDA and NO were significantly lower in the melatonin treated rats when compared with control and sham groups. The levels of GSH in the melatonin treated rats were significantly higher than those of control and sham groups (p < 0.01). The results demonstrate that in this experimental model, intraperitoneal administration of melatonin decreases the extent of peritoneal adhesions and causes a decrease in MDA and NO and an increase in GSH levels. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.lfs.2005.01.024
dc.identifier.endpage1350en_US
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.issue12en_US
dc.identifier.pmid15958275en_US
dc.identifier.scopus2-s2.0-21744437084en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1341en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2005.01.024
dc.identifier.urihttps://hdl.handle.net/11616/93993
dc.identifier.volume77en_US
dc.identifier.wosWOS:000230614800005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectreduced glutathioneen_US
dc.subjectadhesionen_US
dc.titleProtective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn modelen_US
dc.typeArticleen_US

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