Maternal plasma levels of interleukin-6, C-reactive protein, vitamins C, E and A, 8-isoprostane and oxidative status in women with preterm premature rupture of membranes

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dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridIlhan, Nevin/0000-0002-0208-8929
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidIlhan, Nevin/J-5761-2017
dc.contributor.authorIlhan, Nevin
dc.contributor.authorCelik, Ebru
dc.contributor.authorKumbak, Banu
dc.date.accessioned2024-08-04T20:40:04Z
dc.date.available2024-08-04T20:40:04Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Preterm premature rupture of membranes (PPROM) is associated with significant maternal and perinatal morbidity. This study examined maternal oxidative stress in PPROM. Methods: This was a prospective cross-sectional study conducted in a university hospital. A total of 72 pregnant women were recruited into two groups, those with PPROM (38 cases) and those without PPROM (34 controls) matched for gestational age. Plasma interleukin-6, C-reactive protein, vitamins C, E and A, 8-isoprostane, total oxidant status (TOS) and antioxidant status (TAS) were determined for all study participants and the data were compared between the PPROM and control groups. Results: Both case and control groups were comparably matched in age, parity, gestational age and smoking status. There was a significant association between low 8-isoprostane, low vitamin C and high total oxidant status and the occurrence of PPROM (p < 0.001). Conclusions: Plasma vitamin C and 8-isoprostane levels were lower and TOS higher in women with PPROM. Further research is needed to identify robust biological markers for the prevention and also prognosis of PPROM.en_US
dc.identifier.doi10.3109/14767058.2014.916674
dc.identifier.endpage319en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue3en_US
dc.identifier.pmid24749795en_US
dc.identifier.scopus2-s2.0-84923320590en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage316en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2014.916674
dc.identifier.urihttps://hdl.handle.net/11616/96693
dc.identifier.volume28en_US
dc.identifier.wosWOS:000350021100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject8-isoprostaneen_US
dc.subjectearly membrane ruptureen_US
dc.subjectoxidative stressen_US
dc.subjectpregnancyen_US
dc.subjectpreterm premature rupture of membranesen_US
dc.subjecttotal antioxidant statusen_US
dc.subjecttotal oxidant statusen_US
dc.subjectvitamin Cen_US
dc.titleMaternal plasma levels of interleukin-6, C-reactive protein, vitamins C, E and A, 8-isoprostane and oxidative status in women with preterm premature rupture of membranesen_US
dc.typeArticleen_US

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