Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies

Basit Öğe Kaydı
dc.authoridUlukaya, Engin/0000-0003-4875-5472
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authoridSariman, Melda/0000-0003-0898-529X
dc.authoridKaratas, Mert Olgun/0000-0001-8500-2088
dc.authorwosidSariman, Melda/ABB-8877-2021
dc.authorwosidUlukaya, Engin/K-5792-2018
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidSarıman, Melda/AAM-1356-2020
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorOzdemir, Namik
dc.contributor.authorSariman, Melda
dc.contributor.authorGunal, Selami
dc.contributor.authorUlukaya, Engin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:50:35Z
dc.date.available2024-08-04T20:50:35Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHerein, we report the synthesis, characterisation and preliminary biological evaluation of two novel silver(I) complexes of type [AgL2](NO3)(3) (3 and 4) with ionic N-donor benzimidazoles. The complexes have been synthesized by the reaction of 1.5 equivalents of silver nitrate and N-donor benzimidazoles containing an imidazolium core at the 2-position (1 and 2) in ethanol. The X-ray analysis of 4 shows that it has two free imidazolium cores and the charge is balanced with three nitrate anions. A study by the combination of NMR, IR, LC-MS and elemental analysis techniques also suggests that the complexes have this structure both in the solid-state and solution. The complexes are highly soluble and stable in water. Cytotoxicity evaluation against four cancerous human cells and one non-cancerous human cell revealed that the complexes have no significant anti-growth effect. However, the complexes showed a remarkable antimicrobial effect at normalized minimum inhibitory concentrations (normalized MICs) in the range of 33-268 mu M against a panel of microorganisms consisting of Gram-negative and Gram-positive bacteria, and fungi.en_US
dc.description.sponsorshipScientific Research Projects Unit of Ondokuz Mays University [PYO.FEN.1906.19.001]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of Ondokuz Mays University (project no.: PYO.FEN.1906.19.001).en_US
dc.identifier.doi10.1039/d1dt02008k
dc.identifier.endpage11603en_US
dc.identifier.issn1477-9226
dc.identifier.issn1477-9234
dc.identifier.issue33en_US
dc.identifier.pmid34355725en_US
dc.identifier.scopus2-s2.0-85113601876en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage11596en_US
dc.identifier.urihttps://doi.org/10.1039/d1dt02008k
dc.identifier.urihttps://hdl.handle.net/11616/100163
dc.identifier.volume50en_US
dc.identifier.wosWOS:000681720500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeterocyclic Carbene Complexesen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectIn-Vitroen_US
dc.subjectAntibacterialen_US
dc.subjectAgentsen_US
dc.subjectHydrogenationen_US
dc.subjectAnticanceren_US
dc.subjectDrugsen_US
dc.subjectSaltsen_US
dc.titleWater-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu