Microvascular Venous Invasion in Hepatocellular Carcinoma: Why Do Recurrences Occur?

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dc.authoridSAHIN, TEVFIK TOLGA/0000-0002-9132-6115
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authorwosidSAHIN, TEVFIK TOLGA/AAA-9648-2021
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidIsik, Burak/A-6657-2018
dc.contributor.authorIsik, Burak
dc.contributor.authorGonultas, Fatih
dc.contributor.authorSahin, Tolga
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:48:49Z
dc.date.available2024-08-04T20:48:49Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose Hepatocellular carcinoma is the most common primary cancer of the liver. It is almost always associated with cirrhosis and it is usually diagnosed in later stages of the disease. Furthermore, recurrence rate following liver transplantation ranges between 15 and 30%. The most important factor determining the recurrence is vascular invasion. Methods In this review, the issue of microvascular invasion causing hepatocellular carcinoma recurrence is reviewed. Macroscopic vascular invasion is almost easy to diagnose on radiologic evaluation. However, microscopic vascular invasion is almost always diagnosed with pathologic evaluation. On the other hand, microscopic vascular invasion is associated with early recurrences and reduced disease-free survival. The type of vessel that is invaded determines the nature of the spread of the tumor cells. Invasion of the hepatic venous tributaries leads to systemic metastasis whereas portal venous invasions lead to intrahepatic spread of the tumor. Microscopic vascular invasion should be diagnosed before liver transplantation or liver resection in order to deliver the appropriate therapy to the patients. Results Yet, there is no ideal marker to suggest microscopic vascular invasion before any intervention. Markers such as alpha-fetoprotein, des carboxy prothrombin, or gamma-glutamyl transferase have been found to be correlated with microscopic vascular invasion. These parameters are not very efficient to be used in routine clinical practice. Conclusion Therefore, further research is needed to define ideal marker associated with microscopic vascular invasion.en_US
dc.identifier.doi10.1007/s12029-020-00487-9
dc.identifier.endpage1136en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid32839943en_US
dc.identifier.scopus2-s2.0-85089781028en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1133en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00487-9
dc.identifier.urihttps://hdl.handle.net/11616/99479
dc.identifier.volume51en_US
dc.identifier.wosWOS:000562326000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectVascular invasionen_US
dc.subjectPortal vein invasionen_US
dc.subjectHepatic vein invasionen_US
dc.subjectMicroscopic vascular invasionen_US
dc.titleMicrovascular Venous Invasion in Hepatocellular Carcinoma: Why Do Recurrences Occur?en_US
dc.typeReview Articleen_US

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