Elimination of NTproBNP in peritoneal dialysis patients Does peritoneal membrane type make a difference in plasma level and elimination of NTproBNP?

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dc.authoridKoz, Sema T/0000-0002-6342-0200
dc.authoridSahin, Idris/0000-0002-8683-3737
dc.authorwosidKoz, Sema T/AAS-3664-2021
dc.authorwosidSahin, Idris/AAS-4390-2020
dc.contributor.authorKoz, Suleyman
dc.contributor.authorSahin, Idris
dc.contributor.authorTemel, Ismail
dc.contributor.authorKoz, Sema T.
dc.contributor.authorTerzi, Zafer
dc.date.accessioned2024-08-04T20:41:45Z
dc.date.available2024-08-04T20:41:45Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Brain natriuretic peptide and its derivative peptide NTproBNP are utilized to exclude cardiac diseases, and predicting risk of mortality in dialysis patients. Our aim was to evaluate both elimination of NTproBNP through dialysate and a possible relationship between plasma and/or dialysate NTproBNP level and membrane transport status of peritoneal dialysis patients. Methods: 57 plasma (P) and dialysate (D) samples of 44 peritoneal dialysis (PD) patients were analyzed for NTproBNP. Modified peritoneal equilibration test (PET) results and other variables were obtained from the charts. Results: Median (IQR) NTproBNP concentrations (pg/mL x 1,000) in P and D were 3.3 (1 - 13) and 0.5 (0.2 - 3.6), respectively. There was a linear correlation between P-NTproBNP and D-NTproBNP (r = 0.928, p = 0.0001; regression equation was y = 0.897(*)x -0.28). Mean P/D-NTproBNP ratio was 5.5 +/- 0.5. Median P and D-NTproBNP levels by the membrane transport status were aligned as high (H) > high average (HA) > low average (LA), and the difference between H and LA was statistically significant (p < 0.001). Mean arterial pressure (MAP), residual Kt/V and dialysate/plasma ratio of crearinine (D/P Cr) were significant predictors of D-NTproBNP; whereas only MAP and residual Kt/V were significant predictors of P-NTproBNP in multiple regression analysis. Both P-and D-NTproBNP have significant and similar size of correlations with MAP, albumin, D/P Cr ratio, and Na. Conclusions: D-NTproBNP level is similar to 1/5 of P-NTproBNP, and the issue of relationship between membrane transport status and natriuretic peptide levels needs more work.en_US
dc.description.sponsorshipInonu University (INUBAP) [2012/97]en_US
dc.description.sponsorshipThis study was conducted through a grant obtained from Inonu University (INUBAP, Project No: 2012/97).en_US
dc.identifier.doi10.5414/CN108780
dc.identifier.endpage272en_US
dc.identifier.issn0301-0430
dc.identifier.issue5en_US
dc.identifier.pmid27007867en_US
dc.identifier.scopus2-s2.0-84965060079en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://doi.org/10.5414/CN108780
dc.identifier.urihttps://hdl.handle.net/11616/97301
dc.identifier.volume85en_US
dc.identifier.wosWOS:000375759100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofClinical Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnatriuretic peptideen_US
dc.subjectNT-proBNPen_US
dc.subjectBNPen_US
dc.subjecthemodialysisen_US
dc.subjectperitoneal dialysisen_US
dc.titleElimination of NTproBNP in peritoneal dialysis patients Does peritoneal membrane type make a difference in plasma level and elimination of NTproBNP?en_US
dc.typeArticleen_US

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