Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

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dc.authoridBaskin, Esra/0000-0003-4361-8508
dc.authoridCanpolat, Nur/0000-0002-3420-9756
dc.authoridCanpolat, Nur/0000-0002-3420-9756
dc.authoridBalat, Ayse/0000-0002-8904-1348
dc.authoridVidal, Enrico/0000-0003-3963-0803
dc.authoridLiebau, Max Christoph/0000-0003-0494-9080
dc.authoridZurowska, Aleksandra/0000-0002-3354-5344
dc.authorwosidBaskin, Esra/B-5785-2018
dc.authorwosidCandan, Cengiz/ABC-6193-2021
dc.authorwosidCanpolat, Nur/AHE-2082-2022
dc.authorwosidCanpolat, Nur/V-6807-2017
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidVidal, Enrico/AAL-9105-2021
dc.authorwosidLiebau, Max Christoph/K-3470-2019
dc.contributor.authorAzukaitis, Karolis
dc.contributor.authorJu, Wenjun
dc.contributor.authorKirchner, Marietta
dc.contributor.authorNair, Viji
dc.contributor.authorSmith, Michelle
dc.contributor.authorFang, Zhiyin
dc.contributor.authorThurn-Valsassina, Daniela
dc.date.accessioned2024-08-04T20:45:53Z
dc.date.available2024-08-04T20:45:53Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractUrinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1.73 m(2). uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m(2), and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m(2), or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69-0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD.en_US
dc.description.sponsorshipERA-EDTA Research Programme; KfH Foundation for Preventive Medicine; German Federal Ministry of Education and Research [01EO0802]; European Community's Seventh Framework Programme (FP7/2007-2013) [2012-305608]en_US
dc.description.sponsorshipSupport for the 4C Study was received from the ERA-EDTA Research Programme, the KfH Foundation for Preventive Medicine, and the German Federal Ministry of Education and Research (reference number: 01EO0802). FS and MK received support for this study from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement No. 2012-305608 (EURenOmics). FS, EW, FL, EV, and AM are members of the European Reference Network for Rare Kidney Diseases (ERKNet).en_US
dc.identifier.doi10.1016/j.kint.2019.01.035
dc.identifier.endpage221en_US
dc.identifier.issn0085-2538
dc.identifier.issn1523-1755
dc.identifier.issue1en_US
dc.identifier.pmid31005273en_US
dc.identifier.scopus2-s2.0-85064440108en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1016/j.kint.2019.01.035
dc.identifier.urihttps://hdl.handle.net/11616/98762
dc.identifier.volume96en_US
dc.identifier.wosWOS:000472024100029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofKidney Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectCKD progressionen_US
dc.subjectepidermal growth factoren_US
dc.subjectpediatric CKDen_US
dc.titleLow levels of urinary epidermal growth factor predict chronic kidney disease progression in childrenen_US
dc.typeArticleen_US

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