Adrenomedullin and nitric oxide in children with detrusor instability

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dc.authorscopusid55898957300
dc.authorscopusid7005266964
dc.authorscopusid6603965905
dc.authorscopusid6602072091
dc.authorscopusid6701355216
dc.authorscopusid7003317001
dc.contributor.authorBalat A.
dc.contributor.authorSarica K.
dc.contributor.authorÇekmen M.
dc.contributor.authorYürekli M.
dc.contributor.authorYa?ci F.
dc.contributor.authorErba?ci A.
dc.date.accessioned2024-08-04T19:59:34Z
dc.date.available2024-08-04T19:59:34Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDetrusor instability (DI) and detrusor-external sphincter dyssynergia lead to poor bladder emptying and high bladder pressure. Recent results indicate that nitric oxide (NO) is an important transmitter or messenger molecule in autonomic neurotransmission. Adrenomedullin (AM) is a potent vasodilator and natriuretic peptide, originally purified from human pheochromocytoma. Since NO and AM have vasodilatory effects on smooth muscles, we considered them to be of interest in children with DI. We determined the tissue levels of NO and AM in 14 children with DI, and compared these with 6 children with normal bladder activity. Bladder biopsy total nitrite levels (nmol/g tissue) were decreased in children with DI (10.69±0.91 vs. 12.83±0.98, P<0.01). However, AM levels (pmol/g tissue) were increased in the same patients (48.84±3.52 vs. 28.79±1.53, P<0.001). According to our results, decreased NO production probably has a role in the pathophysiology of DI, although increased AM appears to be compensatory. NO may provide a therapeutic target in clinical situations related to DI. However, the functional significance of AM and NO in bladder smooth muscle remains to be determined by further detailed studies.en_US
dc.identifier.doi10.1007/s00467-003-1125-1
dc.identifier.endpage425en_US
dc.identifier.issn0931-041X
dc.identifier.issue5en_US
dc.identifier.pmid12687457en_US
dc.identifier.scopus2-s2.0-0037743665en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-003-1125-1
dc.identifier.urihttps://hdl.handle.net/11616/90727
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenomedullinen_US
dc.subjectDetrusor instabilityen_US
dc.subjectNitric oxideen_US
dc.titleAdrenomedullin and nitric oxide in children with detrusor instabilityen_US
dc.typeArticleen_US

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