Insulin-like growth factor binding proteins in peritoneal fluid of women with minimal and mild endometriosis

Basit Öğe Kaydı
dc.authorscopusid55886237400
dc.authorscopusid34569088300
dc.authorscopusid6602492942
dc.authorscopusid7402031270
dc.authorscopusid6603306052
dc.authorscopusid24562553500
dc.authorscopusid6603869064
dc.contributor.authorTaskin O.
dc.contributor.authorGiudice L.
dc.contributor.authorMangal R.
dc.contributor.authorDunn R.C.
dc.contributor.authorDsupin B.A.
dc.contributor.authorPoindexter A.N.
dc.contributor.authorWiehle R.D.
dc.date.accessioned2024-08-04T19:59:21Z
dc.date.available2024-08-04T19:59:21Z
dc.date.issued1996
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis prospective cohort study was carried out in a university-based infertility clinic to determine the profile of insulin-like growth factor binding proteins (IGFBPs) in patients with mild endometriosis and no obvious mechanical factor contributing to infertility. A total of 26 patients with minimal and mild endometriosis and 10 controls contributed peritoneal fluid at surgery. The variety, expression and levels of IGFBPs were determined by radioimmunoassay and Western ligand blots (WLBs) with quantitation by laser densitometer. A 27 kDa species was significantly lower and a 31 kDa species tended to be lower in patients with endometriosis as determined by quantitative laser densitometer. The levels of IGFBP-3 detected by radioimmunoassay and by WLB were correlated in the control group and in-the patients with endometriosis in the follicular phase but not in patients with endometriosis in the luteal phase. The level of 27 kDa species seen on WLBs did not appear to correspond to IGFBP-1 determined by radioimmunoassay and IGFBP-3 levels in luteal phase endometriosis patients also departed from values determined by radioimmunoassay. These discrepancies suggest a complex system to control levels of IGF in the peritoneum involving multiple binding proteins and proteases. The IGFBPs of patients with endometriosis may contribute to reproductive dysfunction and be able to serve as markers.en_US
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD: R29HD025220en_US
dc.identifier.doi10.1093/oxfordjournals.humrep.a019479
dc.identifier.endpage1746en_US
dc.identifier.issn0268-1161
dc.identifier.issue8en_US
dc.identifier.pmid8921126en_US
dc.identifier.scopus2-s2.0-0029816820en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1741en_US
dc.identifier.urihttps://doi.org/10.1093/oxfordjournals.humrep.a019479
dc.identifier.urihttps://hdl.handle.net/11616/90562
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriosisen_US
dc.subjectIGFBPen_US
dc.subjectInfertilityen_US
dc.subjectPeritoneal fluiden_US
dc.titleInsulin-like growth factor binding proteins in peritoneal fluid of women with minimal and mild endometriosisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu