Nadir bir hemoptizi nedeni: Antifosfolipid antikor sendromu
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Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Solunum Hastalıkları
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Antifosfolipid antikor sendromu (APLS), venöz ve arteriyel trombüsler, tekrarlayan düşükler, trombositopeni ile seyreden ve birçok sistemi tutabilen bir sendromdur. Otuzdokuz yaşında bayan hasta, iki yıldır süren hemoptizi ve nefes darlığı şikayeti ile başvurdu. Özgeçmişinde sekiz düşük hikayesi vardı. Solunum sistemi muayenesi normaldi. Toraks bilgisayarlı tomografisinde her iki akciğer bazallerinde alveoler ödeme bağlı yamalı tarzda buzlu cam görünümü izlendi. Ekokardiyografide pulmoner arter ortalama basıncı 55 mmHg olarak ölçüldü. Laboratuvar incelemelerinde anemi, trombositopeni, eritrosit sedimentasyon hızında yükseklik ve proteinüri saptandı. Aktive parsiyel tromboplastin zamanı ve kanama zamanı uzamıştı. Antikardiyolipin antikor IgG (aCL-lgG) düzeyi yüksek, lupus antikoagülanı (LA) pozitif bulundu ve miks testi pozitifti.Olguya tekrarlayan düşükler, trombositopeni, aCL-lgG yüksekliği, LA pozitifliği, solunum ve renal sistem tutulumu nedeniyle APLS tanısı konuldu. Oral antikoagülan tedavi başlandı. Gebeliği takiben hastada karaciğer ve böbrek yetmezliği gelişmesi üzerine gebelik sonlandırıldı. Ancak multiorgan yetmezliği gelişen hasta kaybedildi. APLS, tekrarlayan hemoptizilerin ayırıcı tanısında görülen nadir nedenlerden biri olarak sunuldu.
Abstract: Thirty-nine years old female presenting with dyspnea and hemoptysis for two years was admitted to the hospital. She had a history of fetal losses for eight times. Physical examination of the chest was found normal. Ground-glass opacification due to alveolar edema at the basis of the lung were seen on lung computed tomography. Laboratory studies had shown anemia, thrombocytopenia, proteinuria and rise of erythrocyte sedimentation rate. Activated partial thrombop-lastin time and bleeding time were prolonged. The level of anticardiolipin antibodies IgG (aCL-lgG), were high and the lupus anticoagulants (LA) were positive. Mix test was positive for inhibitors. Primary antiphospholipid antibody syndrome was diagnosed with presence of the recurrent fetal losses, thrombocytopenia, positive aCL-lgG and LA, cutaneous, pulmonary and renal manifestations. Oral anticoagulant therapy was started. During treatment she got pregnant, but as hepatic and renal insufficiency delivered the pregnancy was terminated. She died because of multiple organ disfunction. We present this case as a rare cause of recurrent hemoptysis.
Abstract: Thirty-nine years old female presenting with dyspnea and hemoptysis for two years was admitted to the hospital. She had a history of fetal losses for eight times. Physical examination of the chest was found normal. Ground-glass opacification due to alveolar edema at the basis of the lung were seen on lung computed tomography. Laboratory studies had shown anemia, thrombocytopenia, proteinuria and rise of erythrocyte sedimentation rate. Activated partial thrombop-lastin time and bleeding time were prolonged. The level of anticardiolipin antibodies IgG (aCL-lgG), were high and the lupus anticoagulants (LA) were positive. Mix test was positive for inhibitors. Primary antiphospholipid antibody syndrome was diagnosed with presence of the recurrent fetal losses, thrombocytopenia, positive aCL-lgG and LA, cutaneous, pulmonary and renal manifestations. Oral anticoagulant therapy was started. During treatment she got pregnant, but as hepatic and renal insufficiency delivered the pregnancy was terminated. She died because of multiple organ disfunction. We present this case as a rare cause of recurrent hemoptysis.
Açıklama
Yıl: 2004Cilt: 15Sayı: 1ISSN: 1300-2961Sayfa Aralığı: 43 - 46Metin Dili:Türkçe
Anahtar Kelimeler
Kaynak
Solunum Hastalıkları
WoS Q Değeri
Scopus Q Değeri
Cilt
15
Sayı
1
Künye
MUTLU L. C,TÜRKER G,GÜLBAŞ G,YILDIRIM Z,AYDOĞDU İ (2004). Nadir bir hemoptizi nedeni: Antifosfolipid antikor sendromu. Solunum Hastalıkları, 15(1), 43 - 46.
