Hepatic Venous Outflow Obstruction After Living-Donor Liver Transplant: Single Center Experience

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dc.authoridsoyer, haci vural/0000-0003-4271-7467
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authorwosidsoyer, haci vural/KAM-0073-2024
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorKoc, Suleyman
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSoyer, Vural
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorBarut, Bora
dc.contributor.authorKutlu, Ramazan
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:45:22Z
dc.date.available2024-08-04T20:45:22Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: In this study, we share our approach for care of patients with hepatic venous outlet obstruction after living-donor liver transplant. Materials and Methods: We retrospectively examined the demographic, clinical, and radiologic data of 35 patients who developed hepatic venous outlet obstruction after living-donor liver transplant. Patients were subgrouped on the basis of onset (8 patients with early onset [< 30 days post-transplant] and 27 patients with late onset [>= 30 days posttransplant]) and postoperative survival (24 survivors, 11 nonsurvivors). Results: Patients ranged in age from 1 to 61 years (24 adults and 11 children). All adult patients had undergone right lobe living-donor liver transplant. In the pediatric group, 8 had undergone left lateral segment and 3 had undergone left lobe living-donor liver transplant. Nineteen adult patients and all 11 pediatric patients underwent hepatic venous reconstruction, with all procedures based on common large-opening drainage models using various vascular graft materials. Development of hepatic venous outlet obstruction occurred at mean posttransplant day 233 +/- 298.5 in the adult patients and mean posttransplant day 139 +/- 97.8 in the pediatric patients. After development of obstruction, the patients underwent 1-6 sessions (1.5 +/- 1.1 sessions) of balloon angioplasty. After the first balloon angioplasty procedure, 25% of the adults and 36.3% of the pediatric patients developed recurrence. The early-onset and late-onset subgroups showed statistically significant differences in serum albumin (P=.01), underlying causes (P<.001), time from transplant to obstruction (P=.02), and time from transplant to last visit (P=.02). The survivor and nonsurvivor subgroups showed statistically significant differences in total bilirubin (P=.03) and time from transplant to last visit (P=.03). Conclusions: Common large-opening reconstruction minimizes hepatic venous outlet obstruction development after living-donor liver transplant. Balloon angioplasty and/or stenting is almost always the first option in the care of this complication.en_US
dc.identifier.doi10.6002/ect.2017.0045
dc.identifier.endpage841en_US
dc.identifier.issn1304-0855
dc.identifier.issn2146-8427
dc.identifier.issue8en_US
dc.identifier.pmid29206088en_US
dc.identifier.scopus2-s2.0-85052055605en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage832en_US
dc.identifier.urihttps://doi.org/10.6002/ect.2017.0045
dc.identifier.urihttps://hdl.handle.net/11616/98435
dc.identifier.volume19en_US
dc.identifier.wosWOS:000680656300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaskent Univen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBalloon angioplastyen_US
dc.subjectVenous outflowen_US
dc.subjectVenous reconstruction modelsen_US
dc.titleHepatic Venous Outflow Obstruction After Living-Donor Liver Transplant: Single Center Experienceen_US
dc.typeArticleen_US

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