Thymoquinone played a protective role against tartrazine- induced

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorDemircigil, Nursena
dc.contributor.authorGul, Mehmet
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorKustepe, Elif Kayhan
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorErman, Mehmet
dc.date.accessioned2024-08-04T20:53:13Z
dc.date.available2024-08-04T20:53:13Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective(s): The current study, the first of its kind in the literature, aimed to observe the toxic effects of Tartrazine, a commonly used dyestuff in industries and foods, on the liver, and investigate whether this toxicity could be eliminated with thymoquinone coadministration. Materials and Methods: 32 male Wistar albino rats were procured from Inonu University Experimental Animals Breeding and Research Center. The rats were randomly assigned to 4 equal groups: Control group, Thymoquinone group, Tartrazine group, and Thymoquinone + Tartrazine group. Rat liver tissue and blood samples were obtained and biochemical and histopathological examinations were conducted on the samples. Results: Tartrazine administration increased the oxidant (malondialdehyde and superoxide dismutase) and oxidative stress index parameters (total oxidant status) in the liver tissue and decreased the antioxidant parameters (glutathione, glutathione peroxidase, catalase, and total antioxidant status) leading to histopathological problems (hematoxylin-eosin staining and Caspase-3 immunoreactivity) and inflammation (tumor necrosis factor-alpha and interleukin-6) in the serum samples. Thymoquinone, on the other hand, improved antioxidant and anti-inflammatory effects. Conclusion: At this time and dose, thymoquinone has a protective effect against tartrazine hepatotoxicity. Thymoquinone can be used as a protective agent against tartrazine toxicity.en_US
dc.description.sponsorshipInonu University Scientific Research Fund; [TYL-2021/2441]en_US
dc.description.sponsorshipAcknowledgment This research was supported by Inonu University Scientific Research Fund (TYL-2021/2441) . The results presented in this paper were part of a student thesis.en_US
dc.identifier.doi10.22038/IJBMS.2022.67341.14763
dc.identifier.endpage106en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue1en_US
dc.identifier.pmid36594061en_US
dc.identifier.scopus2-s2.0-85143664070en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2022.67341.14763
dc.identifier.urihttps://hdl.handle.net/11616/101044
dc.identifier.volume26en_US
dc.identifier.wosWOS:000892346200013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatotoxicityen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.subjectTartrazineen_US
dc.subjectThymoquinoneen_US
dc.titleThymoquinone played a protective role against tartrazine- induceden_US
dc.typeArticleen_US

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