Pomegranate Juice Treatment Prevents Carbon Tetrachloride(CCl4)-induced Testicular Damage in Rats: A Biochemical and Histological Study

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dc.contributor.authorKalkan, Omer Faruk
dc.contributor.authorTurk, Ahmet
dc.contributor.authorCitil, Cihan
dc.contributor.authorUckun, Mirac
dc.contributor.authorOzkaya, Ahmet
dc.contributor.authorYologlu, Ertan
dc.contributor.authorOzay, Yusuf
dc.date.accessioned2026-04-04T13:31:21Z
dc.date.available2026-04-04T13:31:21Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractWe investigated the side effects of carbon tetrachloride (CCl4) on testicular tissue and explored the protective effects of pomegranate juice (PJ) against CCl4 exposure. Twenty-eight male Wistar albino rats were randomly divided into four groups as follows: Control, PJ, CCl4, and CCl4+PJ. We assessed serum testosterone levels and evaluated carboxylesterase (CaE), malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR) and glutathione Stransferase (GST) parameters. Histopathological changes were examined using CD68 immunoreactivity to detect macrophage activity. Analysis revealed a significant increase in CaE activity in the PJ group that compared to the control group (p < 0.05). CCl4 exposure reduced CaE activity, which was partially restored by PJ in the CCl4+PJ group (p < 0.05). PJ also significantly reduced the elevated MDA levels induced by CCl4 (p < 0.05). CCl4 alone decreased the reduced glutathione (GSH) levels (p < 0.05), however PJ had no effect on GSH levels (p > 0.05). Neither CCl4 nor PJ had an effect on glutathione reductase (GR) and glutathione S-transferase (GST) activity (p > 0.05). In conclusion, PJ reversed histological damage and restored reduced testosterone levels. Furthermore, it alleviated CCl4-induced oxidative stress by utilizing an alternative antioxidant system rather than glutathione.
dc.description.sponsorshipDevelopment of Urban Culture and Urban Awareness Financial Support Program [TRC1/18/KBG/0.036]
dc.description.sponsorshipThe chemical composition of the pomegranate juice (PJ) was examined within the framework of the project My City is Ad & imath;yaman, identified by project number: TRC1/18/KBG/0.036. Financial support for the project was provided through the Development of Urban Culture and Urban Awareness Financial Support Program.
dc.identifier.doi10.26873/SVR-2056-2024
dc.identifier.endpage93
dc.identifier.issn1580-4003
dc.identifier.issn2385-8761
dc.identifier.issue2
dc.identifier.orcid0000-0002-9018-8515
dc.identifier.orcid0000-0001-9159-3240
dc.identifier.scopus2-s2.0-105024121501
dc.identifier.scopusqualityQ3
dc.identifier.startpage83
dc.identifier.urihttps://doi.org/10.26873/SVR-2056-2024
dc.identifier.urihttps://hdl.handle.net/11616/108755
dc.identifier.volume62
dc.identifier.wosWOS:001603637600003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Ljubljana Press
dc.relation.ispartofSlovenian Veterinary Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCCl4 toxicity
dc.subjectinfertility
dc.subjectpomegranate juice
dc.subjectcarboxylesterase
dc.subjectoxidative stress
dc.subjecthistopathology
dc.titlePomegranate Juice Treatment Prevents Carbon Tetrachloride(CCl4)-induced Testicular Damage in Rats: A Biochemical and Histological Study
dc.typeArticle

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