Brain diffusion-weighted imaging in diabetic patients with retinopathy

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dc.authoridBozgul, Pembegul/0000-0002-9427-3610;
dc.authorwosidBozgul, Pembegul/AAQ-4951-2020
dc.authorwosidBurulday, Veysel/V-6075-2017
dc.contributor.authorDogan, M.
dc.contributor.authorOzsoy, E.
dc.contributor.authorDoganay, S.
dc.contributor.authorBurulday, V.
dc.contributor.authorFirat, P. G.
dc.contributor.authorOzer, A.
dc.contributor.authorAlkan, A.
dc.date.accessioned2024-08-04T20:35:51Z
dc.date.available2024-08-04T20:35:51Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Our aim was to detect whether there is any change in apparent diffusion coefficients (ADC) levels in different sites of the brain, particularly in areas associated with the vision, in diabetic patients with retinopathy by measuring diffusion-weighted imaging (DWI). Materials and Methods: Conventional magnetic resonance imaging (MRI) and DWI of the brain were obtained from 45 diabetic patients (15 patients with proliferative diabetic retinopathy (group 1), 15 patients with nonproliferative diabetic retinopathy (group 2), 15 diabetic patients without retinopathy (group 3) and from 15 age-matched healthy volunteers (group 4). ADC values of visual cortex, cingulate gyrus, orbitofrontal, dorsomedial and dorsolateral frontal, corona radiate, and thalamus were obtained. Results: The ADC values of visual cortex, cingulate gyrus and orbitofrontal cortex significantly increased in groups 1 and 2 compared to groups 3 and 4 (p < 0.001). The ADC values of visual cortex significantly increased in group 1 compared to group 2 (p < 0.001). The duration of disease and value of HbA1c positively correlated with ADC values of the visual and orbitofrontal cortexes, and cingulate gyrus. Conclusions: We found an increase in ADC values supporting the neuronal loss in some regions, especially in visual center by DWI in the diabetic patients with retinopathy. This result supports the association between diabetic retinopathy and brain injury.en_US
dc.identifier.endpage131en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid22338559en_US
dc.identifier.scopus2-s2.0-84859851062en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://hdl.handle.net/11616/95625
dc.identifier.volume16en_US
dc.identifier.wosWOS:000300114800018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectDiffusion-weighted imagingen_US
dc.subjectVisual centeren_US
dc.subjectADCen_US
dc.titleBrain diffusion-weighted imaging in diabetic patients with retinopathyen_US
dc.typeArticleen_US

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