High postoperative serum levels of surfactant type b as novel prognostic markers for congenital heart surgery

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dc.authorscopusid56365536600
dc.authorscopusid34879586500
dc.authorscopusid55804367800
dc.authorscopusid7004834632
dc.authorscopusid35097485000
dc.authorscopusid6603085168
dc.contributor.authorIsik O.
dc.contributor.authorDisli O.M.
dc.contributor.authorBas T.
dc.contributor.authorAydin H.
dc.contributor.authorKoç M.
dc.contributor.authorKutsal A.
dc.date.accessioned2024-08-04T19:59:14Z
dc.date.available2024-08-04T19:59:14Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description41st Congress of the Brazilian Society of Cardiovascular Surgery, BSCVS 2014 -- 3 April 2014 through 5 April 2014 -- Pernambuco --en_US
dc.description.abstractObjective: Congenital heart diseases are observed in 5 to 8 of every 1000 live births. The presence of a valuable biomarker during the surgical periods may aid the clinician in a more accurate prognosis during treatment. Methods: For this reason, surfactant protein B plasma levels may help to evaluate patients with cardiac problems diminishing the alveolocapillary membrane stability. In this study, plasma levels of this biomarker were measured in the preoperative and postoperative periods. This study was conducted to detect the differences between pulmonary hypertensive and normotensive patients. The differences before and after cardiopulmonary bypass were examined. Results: The differences in cardiopulmonary bypass time, cross-clamp time, inotropic support dose, and duration of intensive care of patients with and without pulmonary hypertensive were found to be statistically significant (P<0.05). The results revealed that this pathophysiological state was related to other variables that were studied. We believe that the differences in preoperative and postoperative SPB levels could be attributed to alveolocapillary membrane damage and alveolar surfactant dysfunction. We found that this pathophysiological condition was significantly associated with postoperative parameters. Conclusion: The findings of the current study showed that surfactant protein B was present in the blood of patients with a congenital heart disease during the preoperative period. Long by-pass times may exert damage to the alveolocapillary membrane in patients with pulmonary hypertension and preoperative heart failure, and it is recommended to keep the option of surfactant therapy in mind during the postoperative course at the intensive care unit before preparing the patients for extubation.en_US
dc.identifier.doi10.5935/1678-9741.20140039
dc.identifier.endpage191en_US
dc.identifier.issn0102-7638
dc.identifier.issue2en_US
dc.identifier.pmid25140468en_US
dc.identifier.scopus2-s2.0-84907369721en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.5935/1678-9741.20140039
dc.identifier.urihttps://hdl.handle.net/11616/90496
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSociedade Brasileira de Cirurgia Cardiovascularen_US
dc.relation.ispartofBrazilian Journal of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiological markersen_US
dc.subjectCongenitalen_US
dc.subjectHeart defectsen_US
dc.subjectHeart surgeryen_US
dc.subjectPulmonary surfactant-associated protein Ben_US
dc.titleHigh postoperative serum levels of surfactant type b as novel prognostic markers for congenital heart surgeryen_US
dc.title.alternativeNíveis séricos pós-operatórios tipo surfactante b elevados como novos marcadores prognósticos para cirurgia cardíaca congênitaen_US
dc.typeConference Objecten_US

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