Combined effect of aerosolized iloprost and oxygen on assessment of pulmonary vasoreactivity in children with pulmonary hypertension

Basit Öğe Kaydı
dc.authorid113476en_US
dc.authorid113274en_US
dc.contributor.authorElkıran, Özlem
dc.contributor.authorKarakurt, Cemşit
dc.contributor.authorKoçak, Gülemdar
dc.date.accessioned2018-01-19T06:42:21Z
dc.date.available2018-01-19T06:42:21Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.descriptionAnadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiologyen_US
dc.description.abstractObjective: The evaluation of pulmonary vascular reactivity plays a significant role in the management of patients with pulmonary hypertension. Inhaled nitric oxide in combination with oxygen (O2) has become widely used as an agent for pulmonary vasodilator testing. However, inhaled nitric oxide is not available in many developing countries. Recently, aerosolized iloprost was suggested as an alternative to nitric oxide for this purpose. In the present study, aerosolized iloprost was used together with O2 in the pulmonary vasoreactivity test of children with severe pulmonary hypertension. Thus, the synergistic effect of both vasodilators was utilized without extending the duration of cardiac catheterization. Methods: The prospective cohort study registered a total of 16 children with severe pulmonary hypertension whose median age was 4.5 years. Hemodynamic parameters were quantified before and after the vasoreactivity test. Increased left-to-right shunt, pulmonary vascular resistance of <6 Woods units (WU)/m2 and a pulmonary-systemic resistance ratio of <0.3, as well as a decrease >10% in the pulmonary vascular resistance and pulmonary-systemic vascular resistance ratio after the vasoreactivity test were accepted as a positive response. The data were analyzed using Wilcoxon signed-rank and the Mann-Whitney U tests. Results: Eleven children gave a positive response to the vasoreactivity test, while 5 children did not respond. Pulmonary vascular resistance dropped from 9.98±1.39 WU/m2 to 5.08±1.05 WU/m2 (p=0.013) and the pulmonary-systemic vascular resistance ratio fell from 0.68±0.08 to 0.32±0.05 (p=0.003) in the children who were responsive. No side effects were observed related to iloprost administration. Conclusion: Administration of inhaled iloprost in combination with O2 for pulmonary vasoreactivity testing can be useful for correctly identifying pulmonary vasoreactivity without extending the duration of cardiac catheterization. (Anadolu Kardiyol Derg 2014; 14: 383-8) Key words: pulmonary hypertension, iloprost, childrenen_US
dc.identifier.citationElkıran, Ö., Karakurt, C., & Koçak, G. (2014). Combined Effect Of Aerosolized İloprost And Oxygen On Assessment Of Pulmonary Vasoreactivity İn Children With Pulmonary Hypertension . Anadolu Kardiyoloji Dergisi-The Anatolian Journal Of Cardiology, 14(4), 0–0.en_US
dc.identifier.endpage4en_US
dc.identifier.issue0en_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://www.journalagent.com/anatoljcardiol/pdfs/AnatolJCardiol_14_4_383_388.pdf
dc.identifier.urihttps://hdl.handle.net/11616/8000
dc.identifier.volume14en_US
dc.language.isoenen_US
dc.publisherAnadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiologyen_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectİloprosten_US
dc.subjectChildrenen_US
dc.titleCombined effect of aerosolized iloprost and oxygen on assessment of pulmonary vasoreactivity in children with pulmonary hypertensionen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Koleksiyonu