The impact of enriched environments on cerebral oxidative balance in rodents: a systematic review of environmental variability effects

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dc.authoridYagin, Fatma Hilal/0000-0002-9848-7958
dc.authoridAlwhaibi, Reem M/0000-0001-5950-0497
dc.authorwosidYagin, Fatma Hilal/ABI-8066-2020
dc.contributor.authorRamos, Tiago Lacerda
dc.contributor.authorFernandes, Matheus Santos de Sousa
dc.contributor.authorFidelis, Debora Eduarda da Silva
dc.contributor.authorSantos, Gabriela Carvalho Jurema
dc.contributor.authorAlbuquerque, Renata B.
dc.contributor.authorFerreira, Diorginis Jose Soares
dc.contributor.authorde Souza, Raphael Fabricio
dc.date.accessioned2024-08-04T20:55:56Z
dc.date.available2024-08-04T20:55:56Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction The present review aimed to systematically summarize the impacts of environmental enrichment (EE) on cerebral oxidative balance in rodents exposed to normal and unfavorable environmental conditions. Methods In this systematic review, four databases were used: PubMed (830 articles), Scopus (126 articles), Embase (127 articles), and Science Direct (794 articles). Eligibility criteria were applied based on the Population, Intervention, Comparison, Outcomes, and Study (PICOS) strategy to reduce the risk of bias. The searches were carried out by two independent researchers; in case of disagreement, a third participant was requested. After the selection and inclusion of articles, data related to sample characteristics and the EE protocol (time of exposure to EE, number of animals, and size of the environment) were extracted, as well as data related to brain tissues and biomarkers of oxidative balance, including carbonyls, malondialdehyde, nitrotyrosine, oxygen-reactive species, and glutathione (reduced/oxidized). Results A total of 1,877 articles were found in the four databases, of which 16 studies were included in this systematic review. The results showed that different EE protocols were able to produce a global increase in antioxidant capacity, both enzymatic and non-enzymatic, which are the main factors for the neuroprotective effects in the central nervous system (CNS) subjected to unfavorable conditions. Furthermore, it was possible to notice a slowdown in neural dysfunction associated with oxidative damage, especially in the prefrontal structure in mice. Discussion In conclusion, EE protocols were determined to be valid tools for improving oxidative balance in the CNS. The global decrease in oxidative stress biomarkers indicates refinement in reactive oxygen species detoxification, triggering an improvement in the antioxidant network.en_US
dc.description.sponsorshipPrincess Nourah bint Abdulrahman University10.13039/501100004242; CAPES; UFPEen_US
dc.description.sponsorshipWe thank all authors for their fundamental contribution to the preparation of this study. The authors appreciate the support from CAPES and UFPE.en_US
dc.identifier.doi10.3389/fnins.2024.1366747
dc.identifier.issn1662-453X
dc.identifier.pmid38665291en_US
dc.identifier.scopus2-s2.0-85191160437en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3389/fnins.2024.1366747
dc.identifier.urihttps://hdl.handle.net/11616/101944
dc.identifier.volume18en_US
dc.identifier.wosWOS:001207516700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectenriched environmenten_US
dc.subjectoxidative stressen_US
dc.subjectbrainen_US
dc.subjectcentral nervous systemen_US
dc.subjectbiochemistryen_US
dc.subjectantioxidantsen_US
dc.titleThe impact of enriched environments on cerebral oxidative balance in rodents: a systematic review of environmental variability effectsen_US
dc.typeArticleen_US

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