Serum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis

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dc.authoridErsoy, Yuksel/0000-0002-8035-4532
dc.authorwosidAltay, Zuhal/AAC-4361-2021
dc.authorwosidErsoy, Yuksel/S-7503-2016
dc.contributor.authorErsoy, Y
dc.contributor.authorÖzerol, E
dc.contributor.authorBaysal, Ö
dc.contributor.authorTemel, I
dc.contributor.authorMacWalter, RS
dc.contributor.authorMeral, Ü
dc.contributor.authorAltay, ZE
dc.date.accessioned2024-08-04T20:12:22Z
dc.date.available2024-08-04T20:12:22Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description12th European Congress of Physical Medicine and Rehabilitation -- JUN 03-08, 2000 -- ANTALYA, TURKEYen_US
dc.description.abstractObjective: To assess and compare serum nitrate and nitrite levels in patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA), and osteoarthritis (OA). Methods: Thirty five patients with RA, 32 patients with AS, and 36 patients with OA were entered into this study. In addition, 30 healthy volunteers acted as a control group. Concentrations of nitrate and nitrite in serum were determined by direct and indirect Griess reactions. C reactive protein and erythrocyte sedimentation rate levels were determined as markers of systemic activity of disease (SAD) in RA and AS groups. Results: Serum nitrate and nitrite levels were found to be higher in patients with AS and RA than in the OA group (p <0.01). In addition, serum nitrate and nitrite levels were higher in all three groups than in the control group (p <0.01). Moreover, serum nitrate and nitrite levels were higher in patients who had SAD than in those who had not in the RA and AS groups (p <0.01 and p <0.05, respectively), and there was a correlation between serum nitrate and nitrite concentrations and SAD variables in patients with RA (Spearman's r(s)=0.414, p <0.05 and r(s)=0.408, p <0.05, respectively) and AS (r(s)=0.421, p <0.05 and r(s)=0.412, p <0.05, respectively). Conclusion: The findings suggest that nitrate and nitrite production is enhanced in patients with inflammatory arthritis compared with OA. In addition, serum nitrate and nitrite levels are enhanced in patients with RA, AS, and OA compared with healthy subjects. Furthermore, there is a correlation between the SAD variables and serum nitrate and nitrite levels in patients with RA and AS.en_US
dc.identifier.doi10.1136/ard.61.1.76
dc.identifier.endpage78en_US
dc.identifier.issn0003-4967
dc.identifier.issue1en_US
dc.identifier.pmid11779766en_US
dc.identifier.scopus2-s2.0-0036145059en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.1136/ard.61.1.76
dc.identifier.urihttps://hdl.handle.net/11616/93386
dc.identifier.volume61en_US
dc.identifier.wosWOS:000172974300021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBritish Med Journal Publ Groupen_US
dc.relation.ispartofAnnals of The Rheumatic Diseasesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxide Synthaseen_US
dc.subjectInflammationen_US
dc.subjectInhibitoren_US
dc.subjectDiseasesen_US
dc.subjectArginineen_US
dc.subjectJointen_US
dc.subjectRatsen_US
dc.titleSerum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritisen_US
dc.typeConference Objecten_US

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