?-Glucan treatment prevents progressive burn ischaemia in the zone of stasis and improves burn healing: An experimental study in rats

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridTurtay, Muhammet Gokhan/0000-0002-1728-8237
dc.authoridCoban, Yusuf/0000-0003-3009-8339;
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidTurtay, Muhammet Gokhan/ABG-7401-2020
dc.authorwosidCoban, Yusuf/AAV-8105-2020
dc.authorwosidFirat, Cemal/D-1292-2012
dc.contributor.authorFirat, Cemal
dc.contributor.authorSamdanci, Emine
dc.contributor.authorErbatur, Serkan
dc.contributor.authorAytekin, Ahmet Hamdi
dc.contributor.authorAk, Muharrem
dc.contributor.authorTurtay, Muhammed Gokhan
dc.contributor.authorCoban, Yusuf Kenan
dc.date.accessioned2024-08-04T20:37:22Z
dc.date.available2024-08-04T20:37:22Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSaving the zone of stasis is one of the major goals of burn specialists. Increasing the tissue tolerance to ischaemia and inhibiting inflammation have been proposed to enable salvage of this zone. After a burn, excessive inflammation, including increased vascular permeability, local tissue oedema and neutrophil activation, causes local tissue damage by triggering vascular thrombosis and blocking capillaries, resulting in tissue ischaemia and necrosis. Oxygen radicals also contribute to tissue damage after a burn. However, macrophages play a pivotal role in the response to burn. We studied beta-glucan because of its many positive systemic effects that are beneficial to burn healing, including immunomodulatory effects, antioxidant effects (free-radical scavenging activity) and effects associated with the reduction of the inflammatory response. There were four test groups in this study with eight rats in each group. Group 1 was the control group, group 2 was administered a local pomade (bacitracin + neomycin sulphate), group 3 received beta-glucan (50 mg kg(-1), orally) + the local pomade and group 4 received beta-glucan. Burns were created using a brass comb model. Macroscopic, histopathological and statistical assessments were performed. Samples were harvested on the 3rd, 7th and 21 days for analysis. The neutrophilic infiltration into the zone of stasis was analysed on day 3. Macrophage infiltration, fibroblast proliferation, angiogenesis and re-epithelialisation ratios in the zone of stasis were analysed on days 7 and 21. The beta-glucan groups (groups 3 and 4) exhibited lower neutrophil counts on the 3rd day, and macrophage infiltration, fibroblast proliferation, angiogenesis and re-epithelialisation were very high in these groups on the 7th day. In particular, re-epithelialisation on the 21st day was significantly better in the beta-glucan groups. This study demonstrated that beta-glucan may prevent neutrophil-dependent tissue damage and burn-induced oxidative injury through its anti-inflammatory and antioxidant properties. We speculate that the inhibition of neutrophil activation preserves vascular patency by preventing capillary blockage. beta-Glucan is also a powerful macrophage stimulator, and is therefore very effective in saving the zone of stasis. (C) 2012 Elsevier Ltd and ISBI. All rights reserved.en_US
dc.description.sponsorshipDepartment of Scientific Research Projects in Inonu Universityen_US
dc.description.sponsorshipThis study was supported by the Department of Scientific Research Projects in Inonu University. We would like to thank all the staff of the Inonu University Animal Research Laboratory for assistance.en_US
dc.identifier.doi10.1016/j.burns.2012.02.031
dc.identifier.endpage112en_US
dc.identifier.issn0305-4179
dc.identifier.issn1879-1409
dc.identifier.issue1en_US
dc.identifier.pmid22469518en_US
dc.identifier.scopus2-s2.0-84872042432en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage105en_US
dc.identifier.urihttps://doi.org/10.1016/j.burns.2012.02.031
dc.identifier.urihttps://hdl.handle.net/11616/95909
dc.identifier.volume39en_US
dc.identifier.wosWOS:000315070900015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBurnsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbeta-Glucanen_US
dc.subjectZone of stasisen_US
dc.subjectBurnen_US
dc.subjectNeutrophilen_US
dc.subjectMacrophageen_US
dc.subjectBurn healingen_US
dc.title?-Glucan treatment prevents progressive burn ischaemia in the zone of stasis and improves burn healing: An experimental study in ratsen_US
dc.typeArticleen_US

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