Comparison of chemopreventive effects of Vitamin E plus selenium versus melatonin in 7,12-dimethylbenz(a) anthracene-induced mouse brain damage

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dc.authoridGenç, Metin Fikret/0000-0002-6244-0517
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidGenç, Metin Fikret/ABI-2169-2020
dc.authorwosid/ABG-9766-2020
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorBatcioglu, K
dc.contributor.authorKaragözler, AA
dc.contributor.authorOzturk, IC
dc.contributor.authorGenc, M
dc.contributor.authorBay, A
dc.contributor.authorOzturk, F
dc.contributor.authorAydogdu, N
dc.date.accessioned2024-08-04T20:13:45Z
dc.date.available2024-08-04T20:13:45Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this work, the protective effect of Vitamin E plus selenium (Vit E + Se) and melatonin against 7,12-dimethylbenz(a)anthracene (7,12DMBA)-induced changes in superoxide dismutase (SOD), glutathione peroxidase (GSHPx), catalase (CAT) and carbonic anhydrase (CA) activities and malonedialdehyde (MDA) levels of mouse brain were compared. 12-month old mice were divided into four groups each including 10 animals. The first group served as control group. The second group was treated with 7,12-DMBA (20 mg/(kg day)). The third group was treated with 7,12-DMBA and Vitamin E (90 mu g/(individual day)) and selenium (1.8 mu g/(individual day)) simultaneously. The fourth group was treated with 7, 12-DMBA and melatonin (4.2 mg/(kg day)) simultaneously. Treatment continued for 21 days after which the mice were sacrificed and brain homogenates were prepared. 7,12-DMBA treated group exhibited significantly decreased levels of brain SOD, GSHPx, CAT and CA activities and increased MDA levels as compared to control. Vitamin E + Se fully or partially restored enzyme inhibition except for SOD. Lipid peroxidation was also reduced in Vitamin E + Se treated group. Melatonin provided a better protection for SOD, GSHPx and CAT, and a plausible protection for CA activity. Protection against lipid peroxidation measured as MDA in melatonin treated group was appreciable although slightly lesser than the protection provided by Vitamin E + Se. The results imply that Vitamin E + Se and melatonin both provide chemoprevention against 7,12-DMBA-induced oxidative stress in mouse brain. (c) 2004 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cdp.2004.06.006
dc.identifier.endpage58en_US
dc.identifier.issn0361-090X
dc.identifier.issue1en_US
dc.identifier.pmid15734218en_US
dc.identifier.scopus2-s2.0-14144251470en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.1016/j.cdp.2004.06.006
dc.identifier.urihttps://hdl.handle.net/11616/93821
dc.identifier.volume29en_US
dc.identifier.wosWOS:000227664000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCancer Detection and Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchemical carcinogenesisen_US
dc.subject7,12-DMBAen_US
dc.subjectfree radicalsen_US
dc.subjectoxidative damageen_US
dc.subjectmelatoninen_US
dc.subjectVitamin Een_US
dc.subjectseleniumen_US
dc.subjectbrainen_US
dc.titleComparison of chemopreventive effects of Vitamin E plus selenium versus melatonin in 7,12-dimethylbenz(a) anthracene-induced mouse brain damageen_US
dc.typeArticleen_US

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