Protective effect of atorvastatin on oxidative stress in streptozotocin-induced diabetic rats independently their lipid-lowering effects

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dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authoridIlhan, Nevin/0000-0002-0208-8929;
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.authorwosidIlhan, Nevin/J-5761-2017
dc.authorwosidGürsoy, Şule/JPW-8593-2023
dc.contributor.authorAktay, Goeknur
dc.contributor.authorGursoy, Sule Oner
dc.contributor.authorUyumlu, Umut
dc.contributor.authorUnuvar, Songuel
dc.contributor.authorIlhan, Nevin
dc.date.accessioned2024-08-04T20:45:41Z
dc.date.available2024-08-04T20:45:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, we investigate the effects of atorvastatin on the lipid profile, oxidative stress, and liver enzyme markers, and its protective activity against diabetic complications, in streptozotocin (STZ)-induced diabetic rats. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), and high-density lipoprotein (HDL) levels, as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme activities, were measured 7 weeks after the administration of STZ and atorvastatin. Thiobarbituric acid reactive substances (TBARS), non-protein associated sulfhydryl (NP-SH), total sulfhydryl (T-SH), and nitric oxide (NO) levels were measured to evaluate oxidative stress. Atorvastatin was found to inhibit ALT and AST activities and to reduce FBG levels in rats with STZ-induced diabetes. Moreover, atorvastatin treatment significantly reduced lipid peroxidation in kidney, heart, and eye tissues (P < 0.001, for all), and resulted in a significant increase in NP-SH levels in brain tissues (P < 0.001). Total NO and nitrate levels increased significantly after atorvastatin treatment (P < 0.01). Our results revealed that atorvastatin has a protective effect against STZ-induced oxidative damage by reducing TBARS levels and increasing NP-SH levels, has a hepatoprotective effect by decreasing ALT and AST activities. It also shows the antihyperglycemic activity by lowering FBG levels.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Department [2011/68]en_US
dc.description.sponsorshipInonu University Scientific Research Projects Department, Grant/Award Number: 2011/68en_US
dc.identifier.doi10.1002/jbt.22295
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue5en_US
dc.identifier.pmid30657622en_US
dc.identifier.scopus2-s2.0-85060244145en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.22295
dc.identifier.urihttps://hdl.handle.net/11616/98616
dc.identifier.volume33en_US
dc.identifier.wosWOS:000467327900014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatorvastatinen_US
dc.subjectdiabetes mellitusen_US
dc.subjectlipid peroxidationen_US
dc.subjectliver enzymesen_US
dc.subjectstreptozotocin (STZ)en_US
dc.titleProtective effect of atorvastatin on oxidative stress in streptozotocin-induced diabetic rats independently their lipid-lowering effectsen_US
dc.typeArticleen_US

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