Hepatitis B/D-Related Hepatocellular Carcinoma. A Clinical Literature Review

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridAtay, ARİF/0000-0001-8163-2357
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidAtay, ARİF/AAK-3579-2020
dc.contributor.authorBaskiran, A.
dc.contributor.authorAtay, A.
dc.contributor.authorBaskiran, D. Y.
dc.contributor.authorAkbulut, S.
dc.date.accessioned2024-08-04T20:50:44Z
dc.date.available2024-08-04T20:50:44Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim Given the current literature data, this article aims to shed light on the epidemiological and clinical effects of HBV, as well as its impact on the development of hepatocellular carcinoma (HCC). Methods A review of the English language literature based on a MEDLINE (PubMed) database was searched. The keywords were cirrhosis, hepatocellular carcinoma, epidemiology, hepatitis delta virus, hepatitis B virus, and co-infection. All references from retrieved papers were reviewed systematically to find additional collection of reports. Results The study has broadly confirmed the contribution of HDV viremia to liver disease and cirrhosis. However, uncertainty over the mechanism of action on HCC development remains. As the recent data has demonstrated, the HCC-HDV has a unique molecular profile which is distinct from that of HBV-HCC. Conclusion Owing to the dependence of HDV on HBV, it is not clear whether HCC is a consequence of the cumulative effect of both HBV and HDV, an effect of the underlying cirrhosis, or a direct oncogenic effect of HDV. Many questions concerning the oncogenic role of HDV remain unanswered. To better understand the role of HDV in carcinogenesis, studies at the molecular level that consider genotype differences should be increased. Multicenter, high-volume, and prospective studies that compare HBV/HDV co-infected and HBV-infected individuals will be pivotal in determining the oncogenic role of HDV.en_US
dc.identifier.doi10.1007/s12029-021-00714-x
dc.identifier.endpage1197en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid34611832en_US
dc.identifier.scopus2-s2.0-85116478862en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1192en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-021-00714-x
dc.identifier.urihttps://hdl.handle.net/11616/100246
dc.identifier.volume52en_US
dc.identifier.wosWOS:000703826900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectCirrhosisen_US
dc.subjectHepatitis delta virusen_US
dc.subjectHepatitis B virusen_US
dc.subjectEpidemiologyen_US
dc.subjectCo-infectionen_US
dc.titleHepatitis B/D-Related Hepatocellular Carcinoma. A Clinical Literature Reviewen_US
dc.typeReview Articleen_US

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