Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes

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dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.authorwosidŞAHİN, Neslihan/F-6402-2019
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorSahin, Neslihan
dc.contributor.authorUstun, Elvan
dc.contributor.authorTutar, Ugur
dc.contributor.authorCelik, Cem
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:50:42Z
dc.date.available2024-08-04T20:50:42Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were characterized by elemental analysis, FT-IR, LC-MS, H-1 NMR, and C-13{H-1} NMR spectroscopy. These new N-heterocyclic carbene precursors and Ag(I)-NHC complexes were evaluated for their antibacterial, antifungal, and antibiofilm activities. The biological activities of synthesized products were compared with standard drugs. All compounds have moderate antibacterial and antibiofilm activities. In particular, while compound 2a was found to be the best inhibitor of E. coli biofilms, while compound 2d inhibited C. albicans biofilm at the highest rate. All the compounds were also analyzed by molecular docking methods with the certain target molecules. (C) 2021 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jorganchem.2021.122082
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85115396195en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2021.122082
dc.identifier.urihttps://hdl.handle.net/11616/100214
dc.identifier.volume954en_US
dc.identifier.wosWOS:000744259200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectBenzimidazolium salten_US
dc.subjectAntimicrobial activityen_US
dc.subjectBiofilm activityen_US
dc.subjectMolecular dockingen_US
dc.titleAntimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexesen_US
dc.typeArticleen_US

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