The Effects of Body Mass Index on Second-Trimester Amniotic Fluid Cytokine and Matrix Metalloproteinase Levels

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorCiftci, Osman
dc.contributor.authorEraslan, Sevil
dc.contributor.authorBasak, Nese
dc.contributor.authorCelik, Ebru
dc.date.accessioned2024-08-04T20:42:55Z
dc.date.available2024-08-04T20:42:55Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of this study was to determine the effects of obesity on amniotic fluid (AF) inflammatory markers in second-trimester AF, testing the hypothesis that there is a relationship between maternal body mass index (BMI) and fetal inflammatory exposure. Methods: AF was obtained from 84 singleton pregnant women undergoing elective amniocentesis for karyotype analysis at 16-24 weeks of gestation between April 2014 and May 2016. The cell-free AF was used to analyze interleukin (IL)-1 beta and IL-6, and matrix metalloproteinase (MMP)-1, MMP-6, and MMP-13. Results: IL-1 beta levels were significantly higher in class II-III obese patients than in class I obese, overweight, and normal weight patients (14.68 +/- 1.37 vs. 13.34 +/- 1.86 vs. 13.00 +/- 2.22 vs. 10.78 +/- 1.92, respectively; p < 0.05). IL-6 levels were lowest in the normal weight group and highest in class II-III obese patients. MMP-1, MMP-6, and MMP-13 levels were also significantly higher in class II-III obese patients than in the other groups. Conclusion: This study demonstrated that the fetuses of class II-III obese women are exposed in utero to higher cytokine and MMP levels than fetuses of lean women. Modification of current cutoff levels of intra-amniotic cytokines and MMPs according to the BMI could improve the accuracy of the prenatal diagnosis of intra-amniotic infection and inflammation. (C) 2017 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000455192
dc.identifier.endpage75en_US
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.issue1en_US
dc.identifier.pmid28103589en_US
dc.identifier.scopus2-s2.0-85010868620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage70en_US
dc.identifier.urihttps://doi.org/10.1159/000455192
dc.identifier.urihttps://hdl.handle.net/11616/97677
dc.identifier.volume83en_US
dc.identifier.wosWOS:000422846700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBody mass indexen_US
dc.subjectCytokinesen_US
dc.subjectInterleukinsen_US
dc.subjectMatrix metalloproteinasesen_US
dc.subjectObesityen_US
dc.subjectPregnancyen_US
dc.titleThe Effects of Body Mass Index on Second-Trimester Amniotic Fluid Cytokine and Matrix Metalloproteinase Levelsen_US
dc.typeArticleen_US

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