Is Macroscopic Portal Vein Tumor Thrombosis of HCC Really an Exclusion for Liver Transplantation?

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorAydin, Cemalettin
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:48:49Z
dc.date.available2024-08-04T20:48:49Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose Hepatocellular carcinoma is a heterogenous group of disease with a spectrum of disease presentations that developed on the setting of liver cirrhosis, although the achievements made in the imaging techniques have enabled the early diagnosis in nearly 60% of the cases in cirrhotic patients. However, hepatobiliary centers and tertiary liver transplant centers have to treat patients with advanced hepatocellular carcinoma with portal venous tumor thrombosis. Methods In this review, liver transplantation results in hepatocellular carcinoma patients with portal vein tumor thrombosis is reviewed. Results Although historically portal venous tumor thrombosis is considered a contraindication for radical surgical procedures such as liver transplantation, current data suggests that patients with hepatocellular carcinoma and macrovascular invasion can achieve favorable outcomes with liver transplantation provided that strict selection criteria is applied. One of the cornerstones of treatment of these patients is development of locoregional therapy such as transarterial chemo and radioembolizations. Transarterial radioembolization is effective in patients if the pretreatment liver failure is mild and the tumor burden including extension to the portal vein is low. Although data is lacking especially radioembolization could even help physicians to differentiate tumors with favorable biologic characteristics. Conclusions Therefore, these patients should be subject of multimodality treatment, and liver transplantation should be offered whenever objective and significant response is obtained by locoregional therapies.en_US
dc.identifier.doi10.1007/s12029-020-00488-8
dc.identifier.endpage1140en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid32833219en_US
dc.identifier.scopus2-s2.0-85089783332en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1137en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00488-8
dc.identifier.urihttps://hdl.handle.net/11616/99482
dc.identifier.volume51en_US
dc.identifier.wosWOS:000562325600004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdvanced hepatocellular carcinomaen_US
dc.subjectDownstagingen_US
dc.subjectTransarterial radioembolizationen_US
dc.subjectTransarterial chemoembolizationen_US
dc.subjectLiver transplantationen_US
dc.titleIs Macroscopic Portal Vein Tumor Thrombosis of HCC Really an Exclusion for Liver Transplantation?en_US
dc.typeReview Articleen_US

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