Virulence Factors and Antibiotic Resistance in Children With Helicobacter pylori Gastritis

Basit Öğe Kaydı
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridözer, ali/0000-0002-7144-4915
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidözer, ali/ABI-2209-2020
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorSelimoglu, Mukadder A.
dc.contributor.authorOtlu, Baris
dc.contributor.authorYildirim, Ozge
dc.contributor.authorOzer, Ali
dc.date.accessioned2024-08-04T20:39:41Z
dc.date.available2024-08-04T20:39:41Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: There are limited data regarding the pattern of Helicobacter pylori (Hp) antibiotic resistance and virulence factors in children. Evaluation of prevalence of drug resistance and virulence-factor genotype in children with Hp gastritis and to investigate whether there is any relation between drug resistance and genotype were our aims in this study. Methods: Ninety-eight children with polymerase chain reaction-positive Hp gastritis were included. Antimicrobial susceptibility was tested by disc diffusion method and polymerase chain reaction assays were used for the determination of virulence factors. Results: The resistance rates to clarithromycin, metronidazole, and amoxicillin were 23.5%, 11.7%, and 3.9%, respectively. All strains carried vacA genotype, and 51%, 70.4%, 49%, 34.7%, and 25.5% were cagA-, cagE-, babA2-, iceA1-, and iceA2-positive, respectively. Of those 98 specimens, 81.6%, 19.4%, 38.8%, and 63.3% carried vacAs1, vacAs2, vacAm1, and vacAm2, respectively. Dominant vacA type was s1am2 (32.7%), followed by s1am1 (14.3%) and s2m2 (12.2%). Significant rates of clarithromycin resistance were observed in cagE-, iceA1-, babA2-, and vacAs1c-positive groups. In those with metronidazole resistance, vacAs1 and vacAs1c were more common (P < 0.05). Conclusions: The cagE-positive and vacA s1a/m2 genotypes, which are correlated with increased antibiotic resistance, were predominant in our population. In countries where Hp infection is prevalent, studies focusing on virulence factors and antibiotic susceptibility may provide anticipation of the prognosis and may be helpful to reduce morbidity and mortality.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2010/62]en_US
dc.description.sponsorshipThis study was funded by Inonu University Scientific Research Projects Unit with the project number of 2010/62.en_US
dc.identifier.doi10.1097/MPG.0000000000000273
dc.identifier.endpage612en_US
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801
dc.identifier.issue5en_US
dc.identifier.pmid24792628en_US
dc.identifier.scopus2-s2.0-84900325646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage608en_US
dc.identifier.urihttps://doi.org/10.1097/MPG.0000000000000273
dc.identifier.urihttps://hdl.handle.net/11616/96441
dc.identifier.volume58en_US
dc.identifier.wosWOS:000335653600022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectvirulenceen_US
dc.subjectantibiotic resistanceen_US
dc.subjectchildrenen_US
dc.subjectHelicobacter pylorien_US
dc.titleVirulence Factors and Antibiotic Resistance in Children With Helicobacter pylori Gastritisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu