Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAKATLI, AYSE NUR/0000-0002-9677-2456
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridPamukcu, Esra/0000-0002-5778-9626
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAKATLI, AYSE NUR/ABH-4455-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidPamukcu, Esra/E-6427-2015
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.contributor.authorSamdanci, Emine Turkmen
dc.contributor.authorHuz, Mustafa
dc.contributor.authorOzhan, Onural
dc.contributor.authorTanbek, Kevser
dc.contributor.authorPamukcu, Esra
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2024-08-04T20:45:37Z
dc.date.available2024-08-04T20:45:37Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats. Materials and methods: Forty Wistar albino rats were equally divided into five groups: control, Mol, Mtx, Mol Mtx, and Mtx Mol. Following treatment, the animals were sacrificed, and liver tissue samples were histopathologically evaluated using Roening grading and Bcl-2 antibody staining. Tissue oxidants, antioxidants, and serum transaminases were measured and statistically compared across all groups. Results: No hepatic fibrosis or steatosis was observed in any of the groups. In the Mtx group, grade 2 liver injury and score 2 Bcl-2 antibody staining were observed; however, in the Mol-Mtx group, these were lower (grade 1, score 1). There were no statistically significant differences in serum transaminase levels among groups. Malondialdehyde levels were higher in all rats that received Mtx, but no differences in myeloperoxidase levels were observed among the groups. Levels of tissue antioxidants, including superoxide dismutase, glutathione (GSH) peroxidase (GSH-Px), and reduced GSH, were significantly higher in the Mol-treated and Mol pre-treated groups. Catalan (CAT) levels were elevated in all Mol-treated groups, but only in that group were CAT levels statistically significantly higher than in the control group. Conclusion: Our results suggest that some oxidant levels could increase following Mtx administration in the liver, possibly contributing to liver damage, whereas Mol could mitigate the histopathological and biochemical effects of hepatotoxicity. However, molecular studies are required to understand the exact mechanisms of these alterations.en_US
dc.identifier.doi10.2147/DDDT.S181550
dc.identifier.endpage21en_US
dc.identifier.issn1177-8881
dc.identifier.pmid30587924en_US
dc.identifier.scopus2-s2.0-85059239138en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S181550
dc.identifier.urihttps://hdl.handle.net/11616/98591
dc.identifier.volume13en_US
dc.identifier.wosWOS:000454363800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmethotrexateen_US
dc.subjectmolsidomineen_US
dc.subjecthepatotoxicityen_US
dc.subjecthepatic fibrosisen_US
dc.titleCytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat studyen_US
dc.typeArticleen_US

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