Effects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained rats

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dc.authoridKilinc, Evren/0000-0002-1697-6580
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.authorwosidKilinc, Evren/A-7409-2011
dc.contributor.authorDuzova, Halil
dc.contributor.authorKarakoc, Yunus
dc.contributor.authorEmre, Memet Hanifi
dc.contributor.authorDogan, Zumrut Yilmaz
dc.contributor.authorKilinc, Evren
dc.date.accessioned2024-08-04T20:31:15Z
dc.date.available2024-08-04T20:31:15Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we aimed to compare the effects of a single bout of acute moderate and strenuous running exercise on the production of interleukin-17 (IL-17), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and inflammatory response of skeletal muscles in regularly trained rats. Eight week old rats were trained by treadmill running 5 days per week for 13 weeks at the durations of 30 min (moderate) and 60 min (strenuous). Two days after the last training session, the animals were subjected to a single bout of moderate or strenuous exercise and serum samples were analyzed for IL-17, IL-6, IL-1ra levels and myeloperoxidase (MPO) activity of gastrocnemius muscle were determined. IL-17 level significantly increased in strenuous exercise group when compared to that of sedentary controls (p < 0.01), On the other hand, only in the moderate exercise group, there was a negative correlation between IL-6 and IL-17 levels (r = 0.857 and p = 0.014). In conclusion, acute single bout of strenuous exercise increased IL-17 production in trained rats and, this cytokine may be involved in inflammatory process of skeletal muscles.en_US
dc.description.sponsorshipInonu University Scientific Research Foundation [2003/33]en_US
dc.description.sponsorshipWe thank to Prof. Dr. Riza Durmaz and Biologist Ahmet Tuna, from the Department of Microbiology, Inonu University Faculty of Medicine, for analyzing of interleukins and Cemal Yerli for performing treadmill exercise.; This research was supported by Inonu University Scientific Research Foundation (Project number: 2003/33)en_US
dc.identifier.endpage224en_US
dc.identifier.issn1303-2968
dc.identifier.issue2en_US
dc.identifier.pmid24149529en_US
dc.identifier.scopus2-s2.0-67650073637en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://hdl.handle.net/11616/94830
dc.identifier.volume8en_US
dc.identifier.wosWOS:000266494600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJournal Sports Science & Medicineen_US
dc.relation.ispartofJournal of Sports Science and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterleukin-17en_US
dc.subjectcytokinesen_US
dc.subjectrunningen_US
dc.subjectexerciseen_US
dc.subjectraten_US
dc.titleEffects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained ratsen_US
dc.typeArticleen_US

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