Re-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes

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dc.authoridbodur, muhittin/0000-0002-2588-8195
dc.authoridSOLMAZ, ISMAIL/0000-0001-7943-9611
dc.authoridKaraoğlu, Pakize/0000-0003-2014-8822
dc.authoridYeniay Süt, Nurşah/0000-0002-8079-7990
dc.authoridKurt, Aysegul Nese Çıtak/0000-0002-7277-3550
dc.authoridtekin, emine/0000-0002-5115-8890
dc.authoridDokurel Çetin, İpek/0000-0002-1820-8980
dc.authorwosidbodur, muhittin/JAN-9435-2023
dc.authorwosidSOLMAZ, ISMAIL/GWM-8928-2022
dc.authorwosidKaraoğlu, Pakize/ADK-2689-2022
dc.authorwosidYeniay Süt, Nurşah/GYR-1155-2022
dc.authorwosidKurt, Aysegul Nese Çıtak/HLX-1035-2023
dc.authorwosidtekin, emine/GPS-9663-2022
dc.authorwosidYılmaz, Deniz/C-8335-2017
dc.contributor.authorYilmaz, Unsal
dc.contributor.authorGucuyener, Kivilcim
dc.contributor.authorYavuz, Merve
dc.contributor.authorOncel, Ibrahim
dc.contributor.authorCanpolat, Mehmet
dc.contributor.authorSaltik, Sema
dc.contributor.authorUnver, Olcay
dc.date.accessioned2024-08-04T20:53:13Z
dc.date.available2024-08-04T20:53:13Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The discovery of anti-myelin oligodendrocyte glycoprotein (MOG)-IgG and anti-aquaporin 4 (AQP4)-IgG and the observation on certain patients previously diagnosed with multiple sclerosis (MS) actually have an antibody-mediated disease mandated re-evaluation of pediatric MS series. Aim: To describe the characteristics of recent pediatric MS cases by age groups and compare with the cohort established before 2015. Method: Data of pediatric MS patients diagnosed between 2015 and 2021 were collected from 44 pediatric neurology centers across Turkiye. Clinical and paraclinical features were compared between patients with dis-ease onset before 12 years (earlier onset) and >= 12 years (later onset) as well as between our current (2015-2021) and previous (< 2015) cohorts. Results: A total of 634 children (456 girls) were enrolled, 89 (14%) were of earlier onset. The earlier-onset group had lower female/male ratio, more frequent initial diagnosis of acute disseminated encephalomyelitis (ADEM), more frequent brainstem symptoms, longer interval between the first two attacks, less frequent spinal cord involvement on magnetic resonance imaging (MRI), and lower prevalence of cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCBs). The earlier-onset group was less likely to respond to initial disease-modifying treatments. Compared to our previous cohort, the current series had fewer patients with onset < 12 years, initial presentation with ADEM-like features, brainstem or cerebellar symptoms, seizures, and spinal lesions on MRI. The female/male ratio, the frequency of sensorial symptoms, and CSF-restricted OCBs were higher than reported in our previous cohort. Conclusion: Pediatric MS starting before 12 years was less common than reported previously, likely due to exclusion of patients with antibody-mediated diseases. The results underline the importance of antibody testing and indicate pediatric MS may be a more homogeneous disorder and more similar to adult-onset MS than previously thought.en_US
dc.identifier.doi10.1016/j.ejpn.2022.08.006
dc.identifier.endpage18en_US
dc.identifier.issn1090-3798
dc.identifier.issn1532-2130
dc.identifier.pmid36137476en_US
dc.identifier.scopus2-s2.0-85143379946en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejpn.2022.08.006
dc.identifier.urihttps://hdl.handle.net/11616/101037
dc.identifier.volume41en_US
dc.identifier.wosWOS:000860343300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofEuropean Journal of Paediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPediatric multiple sclerosisen_US
dc.subjectAnti-MOG-IgGen_US
dc.subjectAnti-AQP4-IgGen_US
dc.subjectAntibodyen_US
dc.subjectDemyelinatingen_US
dc.titleRe-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromesen_US
dc.typeArticleen_US

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