Biological activities of aerial parts extracts of endemic Tanacetum argenteum subsp. argenteum

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dc.contributor.authorŞen, Ali
dc.contributor.authorBingöl Özakpınar, Özlem
dc.contributor.authorTan Birteksöz, Ayşe Seher
dc.contributor.authorKültür, Şükran
dc.contributor.authorUras, Fikriye
dc.contributor.authorBitiş, Leyla
dc.date.accessioned2021-11-24T15:55:44Z
dc.date.available2021-11-24T15:55:44Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: The objective of the present study was to investigate the antimicrobial and anti-proliferative activities of n-hexane, chloroform, methanol and aqueous methanol extracts obtained from Tanacetum argenteum subsp. argenteum aerial parts. Anti- proliferative activity was tested in vitro against four human cancer cell lines (A549: lung adenocarcinoma, Hela; cervix adenocarcinoma, HT-29: colon adenocarcinoma, MCF-7; breast adenocarcinoma) using MTT assay. Antimicrobial activity was assessed by micro-broth dilution technique against Staphylococcus aureus ATCC 29213, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 27853, Proteus mirabilis ATCC 14153, and Candida albicans ATCC 10231. Hexane extract inhibited proliferation of HT-29 and MCF-7 by 75 and 74% while chloroform extract against the same cancer cell lines displayed inhibition of 89 and 73% at the concentration of 30 ?g/mL, respectively. Also, chloroform extract at the same concentration showed significant anti-proliferative activity against A-549 and HeLa with inhibition values of 75% and 62%. Chloroform extract exhibited moderate antibacterial activity against Staphylococcus aureus and S. epidermidis with the MIC values of 625 ?g/mL. Methanol and aqueous methanol extracts showed weak antimicrobial activity against Staphylococcus epidermidis and Candida albicans with MIC values of 1250 ?g/mL. The results showed that n-hexane and chloroform extracts have significant anticancer activity against cancer cell lines used in this study.en_US
dc.identifier.citationŞEN A,ÖZAKPINAR Ö. B,TAN A. S. B,KÜLTÜR Ş,URAS F,BİTİŞ L (2017). Biological activities of aerial parts extracts of endemic Tanacetum argenteum subsp. argenteum. Marmara Pharmaceutical Journal, 21(2), 286 - 290. Doi: 10.12991/marupj.300357en_US
dc.identifier.doi10.12991/marupj.300357en_US
dc.identifier.endpage290en_US
dc.identifier.issn1309-0801
dc.identifier.issue2en_US
dc.identifier.startpage286en_US
dc.identifier.trdizinid302713en_US
dc.identifier.urihttps://doi.org/10.12991/marupj.300357
dc.identifier.urihttps://hdl.handle.net/11616/43367
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/302713
dc.identifier.volume21en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleBiological activities of aerial parts extracts of endemic Tanacetum argenteum subsp. argenteumen_US
dc.typeArticleen_US

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