Schiff base-Poloxamer P85 combination demonstrates chemotherapeutic effect on prostate cancer cells in vitro

Basit Öğe Kaydı
dc.authoridRizvanov, Albert/0000-0002-9427-5739
dc.authoridDoğan, Ayşegül/0000-0003-4160-2270
dc.authoridTelci, Dilek/0000-0002-2793-6533
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridSahin, Fikrettin/0000-0003-1503-5567
dc.authoridDemirci, Selami/0000-0002-6174-1609
dc.authorwosidRizvanov, Albert/H-4486-2013
dc.authorwosidDoğan, Ayşegül/AAD-3223-2019
dc.authorwosidDemirci, Selami/AAC-9963-2020
dc.authorwosidTelci, Dilek/N-5053-2019
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorDemirci, Selami
dc.contributor.authorDogan, Aysegul
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorTelci, Dilek
dc.contributor.authorRizvanov, Albert A.
dc.contributor.authorSahin, Fikrettin
dc.date.accessioned2024-08-04T20:42:52Z
dc.date.available2024-08-04T20:42:52Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractProstate cancer is a multistep and complicated cancer type that is regulated by androgens at the cellular level and remains the second commonest cause of death among men. Discovery and development of novel chemotherapeutic agents enabling rapid tumor cell death with minimal toxic effects to healthy tissues might greatly improve the safety of chemotherapy. The present study evaluates the anti-cancer activity of a novel heterodinuclear copper(II) Mn(II) complex (Schiff base) in combination with poly(ethylene oxide) and poly(propylene oxide) block copolymer (Pluronic) P85. We used assays for cell proliferation, apoptosis, cell migration and invasion, DNA binding and cleavage to elucidate the molecular mechanisms of action, in addition to the antiinflammatory potency of the new combination. The combined treatment of Schiff base and P85 lead to a remarkable anti-cancer effect on prostate cancer cell lines. Cell proliferation was inhibited in Schiff base-P85 treatment. The activity of this formulation is on DNA binding and cleavage and prevents inflammation in in vitro conditions. This is the first study presenting the anti-cancer activity of the present Schiff base derivative and its combination with P85 to treat prostate cancer in vitro. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipDepartment of Genetics and Bioengineering, Yeditepe University, Turkeyen_US
dc.description.sponsorshipThe work was supported by the Department of Genetics and Bioengineering, Yeditepe University, Turkey.en_US
dc.identifier.doi10.1016/j.biopha.2016.11.101
dc.identifier.endpage501en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid28012929en_US
dc.identifier.scopus2-s2.0-85007061023en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage492en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2016.11.101
dc.identifier.urihttps://hdl.handle.net/11616/97643
dc.identifier.volume86en_US
dc.identifier.wosWOS:000395523800061en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchiff baseen_US
dc.subjectP85en_US
dc.subjectPoloxameren_US
dc.subjectProstate canceren_US
dc.subjectChemotherapyen_US
dc.titleSchiff base-Poloxamer P85 combination demonstrates chemotherapeutic effect on prostate cancer cells in vitroen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu