The beneficial effects of ivabradine against myocardial damage induced by isoproterenol in rats

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dc.contributor.authorPolat, Alaadın
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Seyhan
dc.contributor.authorYıldız, Azibe
dc.contributor.authorTanriverdi, Lokman Hekim
dc.contributor.authorGunata, Mehmet
dc.date.accessioned2026-04-04T13:14:37Z
dc.date.available2026-04-04T13:14:37Z
dc.date.issued2023
dc.departmentİnönü Üniversitesi
dc.description.abstractWe aimed to investigate the potential benefits of two doses of ivabradine (IVA)-an If sodium channel blocker against isoproterenol (ISO)-induced myocardial damage in rats.The rats were randomly divided into 4 groups: Control group (n=8); Saline was administered, ISO group (n=12); 150 mg/kg ISO was administered for 2 days, ISO+IVA (1 mg/kg) group (n=12); 1 mg/kg IVA was administered for 4 days in addition to ISO. ISO+IVA (10 mg/kg) group (n=12): 10 mg/kg IVA was administered for 4 days in addition to ISO. Thereafter, hemodynamic, histopathological, and biochemical studies were performed. In the ISO+IVA (1 mg/kg) and ISO+IVA (10 mg/kg) groups, ISO-induced myocardial changes including an increase in density of granulation tissue and degenerated cardiomyocyte were equally decreased. HR was mildly reduced, and arterial blood pressures were slightly increased in the IVA-treated groups versus the ISO group. In the hearts of IVA-treated groups, malondialdehyde (MDA) levels were significantly reduced and glutathione (GSH) level and catalase (CAT) activity were mildly increased compared to the ISO group. Elevation of GSH and CAT activity were more pronounced in the ISO+IVA (10 mg/kg) group. Our results indicate that both 1 mg/kg and 10 mg/kg doses of IVA are effective against heart damage induced by ISO via its negative chronotropic, anti-oxidant (dose-dependent), anti-inflammatory and anti-degenerative properties.
dc.identifier.doi10.5455/medscience.2023.03.042
dc.identifier.endpage673
dc.identifier.issn2147-0634
dc.identifier.issue3
dc.identifier.startpage667
dc.identifier.trdizinid1259439
dc.identifier.urihttps://doi.org/10.5455/medscience.2023.03.042
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1259439
dc.identifier.urihttps://hdl.handle.net/11616/107344
dc.identifier.volume12
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250329
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleThe beneficial effects of ivabradine against myocardial damage induced by isoproterenol in rats
dc.typeArticle

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