Mesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent model

Basit Öğe Kaydı
dc.authoridAli, Shakir/0000-0002-4002-1231
dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidAli, Shakir/M-3679-2017
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorOrhan, Cemal
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Nurhan
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorAli, Shakir
dc.date.accessioned2024-08-04T20:44:35Z
dc.date.available2024-08-04T20:44:35Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Mesozeaxanthin (MZ) is a macular carotenoid which has been reported to have a number of pharmacological properties, including the antioxidant, and anticarcinogenic property, and has been stated to decrease the hepatocyte lipid content. Objective: In this study, we investigated the effect of MZ on cardio-metabolic health risk (CMHR) and its probable mechanisms of action in rats fed a high-fat diet (HFD). Design: Rats were randomly divided into four groups consisting of (i) Control, (ii) MZ, (iii) HFD, and (iv) HFD+MZ. Results: MZ treatment increased the antioxidant enzyme activities and helped improve the liver function. The treatment alleviated CMHR and decreased the level of nuclear factor kappa B (NF-kappa B p65) and tumor necrosis factor-alpha (TNF-alpha). The levels of hepatic peroxisome proliferator-activated receptor gamma (PPAR-gamma), phosphorylated insulin receptor substrate 1 (p-IRS-1), beta,beta-carotene 9', 10'-oxygenase 2 (BCO2) and nuclear factor erythroid 2-related factor 2 (Nrf2), which decrease in HFD rats, were found to be significantly higher in MZ supplemented animals. Conclusion: MZ has antioxidant and anti-inflammatory properties and can is reported in this study toprotect against fatty liver and cardio-metabolic syndrome, possibly through regulation of PPAR-gamma, IRS-1, Nrf2 and NF-kappa B proteins, in an insulin-resistant rodent model.en_US
dc.description.sponsorshipOmniActive Health Technologies Inc. (NJ, USA)en_US
dc.description.sponsorshipThis study was sponsored by OmniActive Health Technologies Inc. (NJ, USA).en_US
dc.identifier.doi10.1080/16546628.2017.1353360
dc.identifier.issn1654-6628
dc.identifier.issn1654-661X
dc.identifier.pmid28804442en_US
dc.identifier.scopus2-s2.0-85048392499en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/16546628.2017.1353360
dc.identifier.urihttps://hdl.handle.net/11616/98333
dc.identifier.volume61en_US
dc.identifier.wosWOS:000406221100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofFood & Nutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-fat dieten_US
dc.subjectinsulin resistanceen_US
dc.subjectliveren_US
dc.subjectmesozeaxanthinen_US
dc.subjectratsen_US
dc.titleMesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu